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MARCHF2
Identifiers
Aliases	MARCHF2, MARCH-II, RNF172, HSPC240, membrane associated ring-CH-type finger 2, MARCH2
External IDs	OMIM: 613332; MGI: 1925915; HomoloGene: 9539; GeneCards: MARCHF2; OMA:MARCHF2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.2 Start 8,413,270 bp End 8,439,017 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B1 Start 33,904,666 bp End 33,937,644 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart monocyte C1 segment muscle layer of sigmoid colon right frontal lobe muscle of thigh right auricle right coronary artery granulocyte left ventricle Top expressed in blood fetal liver hematopoietic progenitor cell tibiofemoral joint spleen right kidney muscle of thigh interventricular septum granulocyte skeletal muscle tissue superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein binding metal ion binding ubiquitin-protein transferase activity transferase activity Cellular component integral component of membrane lysosomal membrane endosome lysosome endosome membrane endoplasmic reticulum membrane cytoplasmic vesicle membrane endoplasmic reticulum Biological process endocytosis protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51257 224703 Ensembl ENSG00000099785 ENSMUSG00000079557 UniProt Q9P0N8 Q99M02 RefSeq (mRNA) NM_001005415 NM_001005416 NM_016496 NM_001369776 NM_001369777 NM_001369778 NM_001369779 NM_001252480 NM_145486 RefSeq (protein) NP_001005415 NP_001005416 NP_057580 NP_001356705 NP_001356706 NP_001356707 NP_001356708 NP_001239409 NP_663461 Location (UCSC) Chr 19: 8.41 – 8.44 Mb Chr 17: 33.9 – 33.94 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase MARCH2 is an enzyme that in humans is encoded by the MARCH2 gene. It is a member of the MARCH family of E3 ligases, and plays an important role in the turnover of membrane proteins. MARCH2 has been shown to negatively regulate NF-κB essential modulator function upon viral and bacterial infections.

Gene name error in Excel

Like the other MARCH and septin genes, care must be exercised when analyzing genetic data containing the MARCH2 gene in Microsoft Excel. This is due to Excel's autocorrect feature treating the MARCH gene as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error. The issue can be prevented by using an alias name such as MARCHF2, prepending with an apostrophe ('), or preformatting the cell as text.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000099785 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000079557 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
6. Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Früh K (February 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". Journal of Virology. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
7. "Entrez Gene: MARCH2 membrane-associated ring finger (C3HC4) 2".
8. Zhang Y, Lu J, Liu X (May 2018). "MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation". Virology. 518: 293–300. doi:10.1016/j.virol.2018.02.003. PMID 29573664.
9. Chathuranga K, Kim TH, Lee H, Park JS, Kim JH, Chathuranga WA, Ekanayaka P, Choi YJ, Lee CH, Kim CJ, Jung JU, Lee JS (2020). "Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2". The EMBO Journal. 39 (21): e105139. doi:10.15252/embj.2020105139. PMC 7604578. PMID 32935379. S2CID 221745904.
10. Zeeberg BR, Riss J, Kane DW, Bussey KJ, Uchio E, Linehan WM, et al. (June 2004). "Mistaken identifiers: gene name errors can be introduced inadvertently when using Excel in bioinformatics". BMC Bioinformatics. 5 (1): 80. doi:10.1186/1471-2105-5-80. PMC 459209. PMID 15214961.
11. Ziemann M, Eren Y, El-Osta A (August 2016). "Gene name errors are widespread in the scientific literature". Genome Biology. 17 (1): 177. doi:10.1186/s13059-016-1044-7. PMC 4994289. PMID 27552985.

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Nakamura N, Fukuda H, Kato A, Hirose S (April 2005). "MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking". Molecular Biology of the Cell. 16 (4): 1696–710. doi:10.1091/mbc.E04-03-0216. PMC 1073653. PMID 15689499.
• Fukuda H, Nakamura N, Hirose S (January 2006). "MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II". Journal of Biochemistry. 139 (1): 137–45. doi:10.1093/jb/mvj012. PMID 16428329.

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