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MCM3AP

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Protein-coding gene in the species Homo sapiens
MCM3AP
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4DHX

Identifiers
AliasesMCM3AP, GANP, MAP80, SAC3, minichromosome maintenance complex component 3 associated protein, PNRIID
External IDsOMIM: 603294; MGI: 1930089; HomoloGene: 2902; GeneCards: MCM3AP; OMA:MCM3AP - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)
Chromosome 21 (human)Genomic location for MCM3APGenomic location for MCM3AP
Band21q22.3Start46,235,133 bp
End46,286,297 bp
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)
Chromosome 10 (mouse)Genomic location for MCM3APGenomic location for MCM3AP
Band10|10 C1Start76,304,761 bp
End76,351,691 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • tibial nerve

  • right uterine tube

  • gastrocnemius muscle

  • body of uterus

  • gastric mucosa

  • right ovary

  • right lobe of thyroid gland

  • cerebellar hemisphere

  • right hemisphere of cerebellum
Top expressed in
  • saccule

  • otic vesicle

  • zygote

  • primary oocyte

  • otic placode

  • secondary oocyte

  • Rostral migratory stream

  • granulocyte

  • renal corpuscle

  • ventricular zone
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8888

54387

Ensembl

ENSG00000160294

ENSMUSG00000001150

UniProt

O60318

Q9WUU9

RefSeq (mRNA)

NM_003906

NM_019434

RefSeq (protein)

NP_003897

NP_062307

Location (UCSC)Chr 21: 46.24 – 46.29 MbChr 10: 76.3 – 76.35 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

80 kDa MCM3-associated protein is a protein that in humans is encoded by the MCM3AP gene.

Function

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is an MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.

Interactions

MCM3AP has been shown to interact with:

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000160294Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000001150Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takei Y, Tsujimoto G (September 1998). "Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization". J. Biol. Chem. 273 (35): 22177–80. doi:10.1074/jbc.273.35.22177. PMID 9712829.
  6. ^ "Entrez Gene: MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein".
  7. Takei Y, Assenberg M, Tsujimoto G, Laskey R (November 2002). "The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3". J. Biol. Chem. 277 (45): 43121–5. doi:10.1074/jbc.C200442200. PMID 12226073.
  8. Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N (April 2000). "A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication". Blood. 95 (7): 2321–8. doi:10.1182/blood.V95.7.2321. PMID 10733502.
  9. Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–8. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110.

Further reading

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Germinal-center associated nuclear protein (MCM3AP)


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