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MED11
Identifiers
Aliases	MED11, HSPC296, mediator complex subunit 11
External IDs	OMIM: 612383; MGI: 1913422; HomoloGene: 32630; GeneCards: MED11; OMA:MED11 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.2 Start 4,731,428 bp End 4,733,608 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B3 Start 70,342,745 bp End 70,344,553 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex skin of arm granulocyte apex of heart myocardium of left ventricle gonad cardiac muscle tissue of right atrium Top expressed in internal carotid artery external carotid artery granulocyte yolk sac molar epiblast mesenteric lymph nodes paraventricular nucleus of hypothalamus embryo medial vestibular nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coregulator activity protein binding ubiquitin protein ligase activity Cellular component mediator complex nucleus ubiquitin ligase complex Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated protein ubiquitination transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 400569 66172 Ensembl ENSG00000161920 ENSMUSG00000018923 UniProt Q9P086 Q9D8C6 RefSeq (mRNA) NM_001305000 NM_001001683 NM_025397 RefSeq (protein) NP_001001683 NP_001291929 NP_079673 Location (UCSC) Chr 17: 4.73 – 4.73 Mb Chr 11: 70.34 – 70.34 Mb PubMed search
Wikidata
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Mediator complex subunit 11 (Med11) is a protein that in humans is encoded by the MED11 gene.

Function

Med11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.

See also

• Mediator

References

1. ^ GRCh38: Ensembl release 89: ENSG00000161920 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000018923 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Mediator complex subunit 11".
6. Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17). American Society for Biochemistry & Molecular Biology (ASBMB): 15123–7. doi:10.1074/jbc.c300054200. PMID 12584197.

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