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MED22
Identifiers
Aliases	MED22, MED24, SURF5, surf-5, mediator complex subunit 22, SRB6
External IDs	OMIM: 185641; MGI: 98446; HomoloGene: 4913; GeneCards: MED22; OMA:MED22 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.2 Start 133,338,312 bp End 133,348,131 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 A3|2 19.09 cM Start 26,795,274 bp End 26,800,689 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood sural nerve muscle layer of sigmoid colon right coronary artery body of uterus gastric mucosa prefrontal cortex apex of heart left uterine tube Top expressed in ventricular zone spermatocyte Rostral migratory stream ganglionic eminence primary oocyte medial ganglionic eminence secondary oocyte zygote lip lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coregulator activity protein binding Cellular component cytoplasm mediator complex nucleus Biological process regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6837 20933 Ensembl ENSG00000281022 ENSG00000148297 ENSMUSG00000015776 UniProt Q15528 Q5T8T8 Q62276 RefSeq (mRNA) NM_181491 NM_006752 NM_133640 NM_001033908 NM_011513 NM_001378786 NM_001378787 NM_001378788 RefSeq (protein) NP_598395 NP_852468 NP_001029080 NP_035643 NP_001365715 NP_001365716 NP_001365717 Location (UCSC) Chr 9: 133.34 – 133.35 Mb Chr 2: 26.8 – 26.8 Mb PubMed search
Wikidata
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Mediator of RNA polymerase II transcription subunit 22 is an enzyme that in humans is encoded by the MED22 gene.

Function

This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.

Interactions

MED22 has been shown to interact with MED30.

References

1. ^ ENSG00000148297 GRCh38: Ensembl release 89: ENSG00000281022, ENSG00000148297 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000015776 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yon J, Jones T, Garson K, Sheer D, Fried M (Mar 1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Human Molecular Genetics. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID 8499913.
6. Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
7. ^ "Entrez Gene: SURF5 surfeit 5".
8. Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.

Further reading

• De Falco S, Russo G, Angiolillo A, Pietropaolo C (Apr 1993). "Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene". Gene. 126 (2): 227–35. doi:10.1016/0378-1119(93)90371-9. PMID 8482538.
• Garson K, Duhig T, Armes N, Colombo P, Fried M (Nov 1995). "Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene". Genomics. 30 (2): 163–70. doi:10.1006/geno.1995.9889. PMID 8586415.
• Garson K, Duhig T, Fried M (1997). "Tissue-specific processing of the Surf-5 and Surf-4 mRNAs". Gene Expression. 6 (4): 209–18. PMC 6148271. PMID 9196076.
• Duhig T, Ruhrberg C, Mor O, Fried M (Aug 1998). "The human Surfeit locus". Genomics. 52 (1): 72–8. doi:10.1006/geno.1998.5372. PMID 9740673.
• Angiolillo A, Russo G, Porcellini A, Smaldone S, D'Alessandro F, Pietropaolo C (Feb 2002). "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts". Gene. 284 (1–2): 169–78. doi:10.1016/S0378-1119(02)00379-7. PMID 11891058.
• Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
• Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW (Dec 2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
• Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.

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