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MIR1269A

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MIR1269A
Identifiers
AliasesMIR1269A, MIR1269, MIRN1269, hsa-mir-1269, hsa-mir-1269a, microRNA 1269a
External IDsGeneCards: MIR1269A; OMA:MIR1269A - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)
Chromosome 4 (human)Genomic location for MIR1269AGenomic location for MIR1269A
Band4q13.2Start66,276,824 bp
End66,276,928 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left adrenal cortex

  • right lobe of liver

  • gastrocnemius muscle

  • blood

  • thoracic aorta

  • ascending aorta

  • granulocyte

  • subcutaneous adipose tissue

  • dorsolateral prefrontal cortex

  • skin of leg
    n/a
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

100302177

n/a

Ensembl

ENSG00000221563

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 4: 66.28 – 66.28 Mbn/a
PubMed searchn/a
Wikidata
View/Edit Human

MicroRNA 1269a is a protein that in humans is encoded by the MIR1269A gene.

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. .

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000221563 – Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: MicroRNA 1269a". Retrieved 2013-12-19.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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