MSC may refer to:
Computers
- Message Sequence Chart
- Microelectronics Support Centre of UK Rutherford Appleton Laboratory
- MIDI Show Control
- Mouse Systems Corporation, a former manufacturer of computer mouses
- MSC Malaysia (formerly known as Multimedia Super Corridor)
- USB mass storage device class (USB MSC)
- Mobile Switching Center, of a phone network
- Management saved console
Corporations
- Managed service company, a UK company structure
- Metric Systems Corporation
- Mediterranean Shipping Company
- MSC Air Cargo, cargo airline owned by Mediterranean Shipping Company
- MSC Industrial Direct, formerly Manhattan Supply Company
- MSC Software, simulation software company, formerly MacNeal-Schwendler Corporation
Education
- Master of Science, usually MSc or M.Sc.
- Mastère en sciences, French degree
- Memorial Student Center, Texas A&M University, US
- Mesa State College, Colorado, United States
- Mount Saint Charles Academy, Catholic school in Rhode Island, United States
- Munsang College, Hong Kong
- Marinduque State College, Philippines, now Marinduque State University
Military
- Medical Service Corps, of the US military forces
- Military Sealift Command, US Navy
- Military Staff Committee, United Nations body
- Munich Security Conference, annual international security conference
- A US Navy hull classification symbol: Minesweeper, coastal (MSC)
Religious
Science
- Maryland Science Center
- Miles of Standard Cable, former telephony unit of loss
- Manned Spacecraft Center, later Johnson Space Center
- Mathematics Subject Classification
- Messinian salinity crisis, a geological event during which the Mediterranean Sea dried up
- Meteorological Service of Canada
Biology
- Mechanosensitive channels
- Mesenchymal stem cell, a multipotent stromal cell
- MSC (gene), a human gene encoding the protein musculin
- Mammary secretory carcinoma, a rare form of the breast cancers
Seafaring
- Maritime Safety Committee, a United Nations body
- Marine Stewardship Council, concerned with sustainable fishing
- Manchester Ship Canal, England
- Mediterranean Shipping Company, a container shipping company
- MSC Cruises, a cruise line
Sports
- Michael Schumacher's abbreviation used in Formula 1
- Metro Suburban Conference, athletic conference, Illinois, US
- Mid-South Conference, US athletic conference
- Mobile Legends: Bang Bang Mid Season Cup, annual international MLBB esports tournament
- Mobile Legends: Bang Bang Southeast Asia Cup, former tournament for regional Southeast Asia during 2017–2023
- Mohammedan Sporting Club (Dhaka), Bangladesh
- Mohammedan Sporting Club (Chittagong), a branch in Chittagong
- Mohammedan Sporting Club (Kolkata)
- Mombasa Sports Club, Kenya
Other
- Air Cairo (ICAO designator), Egyptian airline
- Falcon Field (Arizona) (IATA code: MSC), airport in Mesa, Arizona, USA
- Mail services center
- Manpower Services Commission, a British government agency, 1974–1987
- Matthews Southern Comfort, a country rock/folk rock band
- Member of State Council
- Meritorious Service Cross, a Canadian decoration bestowed by the Monarch
- Metropolitan Special Constabulary, London, England
- Motorcycle Stability Control, an ABS variant
- Movimiento Scout Católico (Catholic Scout Movement), Spain
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