MSK may refer to the following:
- Marinestosstruppkompanie, German naval assault troops
- Marske railway station, England, National Rail station code
- Medullary sponge kidney
- Medvedev–Sponheuer–Karnik scale, a macroseismic intensity scale
- Memorial Sloan Kettering Cancer Center
- Minimum-shift keying radio modulation
- Mohammad Sidique Khan, a perpetrator of the July 2005 London bombings
- Moscow
- Moscow Time
- Common abbreviation for Human musculoskeletal system
- Museum of Fine Arts, Ghent (Museum voor Schone Kunsten), Belgium
- Premier Sports, UK TV channel, formerly MSK
- MSK (professional wrestling), a professional wrestling tag team
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