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MSRB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MAO
Identifiers
Aliases	MSRB1, SELR, SELX, SEPX1, SepR, HSPC270, methionine sulfoxide reductase B1, SELENOX, SELENOR
External IDs	OMIM: 606216; MGI: 1351642; HomoloGene: 8455; GeneCards: MSRB1; OMA:MSRB1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 1,938,229 bp End 1,943,199 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 A3.3|17 12.53 cM Start 24,955,616 bp End 24,961,752 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood right lobe of liver body of pancreas trabecular bone thoracic diaphragm monocyte granulocyte bone marrow periodontal fiber human kidney Top expressed in granulocyte left lobe of liver parotid gland sternocleidomastoid muscle temporal muscle triceps brachii muscle tibiofemoral joint interventricular septum stroma of bone marrow digastric muscle More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor oxidoreductase activity actin binding zinc ion binding metal ion binding methionine-R-sulfoxide reductase activity peptide-methionine (R)-S-oxide reductase activity L-methionine-(R)-S-oxide reductase activity protein binding Cellular component cytoplasm cytosol cytoskeleton nucleus actin cytoskeleton cellular component Biological process immune system process actin filament polymerization innate immune response response to oxidative stress protein repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51734 27361 Ensembl ENSG00000198736 ENSMUSG00000075705 UniProt Q9NZV6 Q9JLC3 RefSeq (mRNA) NM_016332 NM_001382264 NM_001382265 NM_013759 NM_001346668 RefSeq (protein) NP_057416 NP_001369193 NP_001369194 NP_001333597 NP_038787 Location (UCSC) Chr 16: 1.94 – 1.94 Mb Chr 17: 24.96 – 24.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase B (MsrB) family, and it is expressed in a variety of adult and fetal tissues.

See also

• MSRA (gene)
• MSRB2
• Methionine oxidation

References

1. ^ GRCh38: Ensembl release 89: ENSG00000198736 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000075705 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lescure A, Gautheret D, Carbon P, Krol A (Feb 2000). "Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif". J Biol Chem. 274 (53): 38147–54. doi:10.1074/jbc.274.53.38147. PMID 10608886.
6. ^ "Entrez Gene: SEPX1 selenoprotein X, 1".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Kryukov GV, Kryukov VM, Gladyshev VN (1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi:10.1074/jbc.274.48.33888. PMID 10567350.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Moskovitz J, Singh VK, Requena J, et al. (2002). "Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity". Biochem. Biophys. Res. Commun. 290 (1): 62–5. doi:10.1006/bbrc.2001.6171. PMID 11779133.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kim HY, Gladyshev VN (2004). "Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases". Mol. Biol. Cell. 15 (3): 1055–64. doi:10.1091/mbc.E03-08-0629. PMC 363075. PMID 14699060.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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• Genes on human chromosome 16
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