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MXRA8
Identifiers
Aliases	MXRA8, matrix remodeling associated 8, ASP3
External IDs	OMIM: 617293; MGI: 1922011; HomoloGene: 11500; GeneCards: MXRA8; OMA:MXRA8 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.33 Start 1,352,689 bp End 1,361,777 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 E2|4 87.58 cM Start 155,924,137 bp End 155,928,545 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium tibial nerve decidua canal of the cervix body of uterus right coronary artery right ovary gallbladder left ovary ascending aorta Top expressed in calvaria right lung ankle body of femur left lung right lung lobe stroma of bone marrow molar genital tubercle trachea More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component integral component of membrane cell surface extracellular exosome membrane endoplasmic reticulum lumen nucleus cytoplasm plasma membrane bicellular tight junction cell junction cell projection ciliary membrane Biological process establishment of glial blood-brain barrier post-translational protein modification viral process cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54587 74761 Ensembl ENSG00000162576 ENSMUSG00000029070 UniProt Q9BRK3 Q9DBV4 RefSeq (mRNA) NM_032348 NM_001282582 NM_001282583 NM_001282584 NM_001282585 NM_024263 RefSeq (protein) NP_001269511 NP_001269512 NP_001269513 NP_001269514 NP_115724 NP_077225 Location (UCSC) Chr 1: 1.35 – 1.36 Mb Chr 4: 155.92 – 155.93 Mb PubMed search
Wikidata
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Matrix remodeling-associated protein 8 is a protein that in humans is encoded by the MXRA8 gene.

MXRA8 protein is a receptor for multiple arthritogenic alphaviruses, including chikungunya, Ross River, Mayaro and O'nyong nyong viruses.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000162576 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000029070 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Matrix remodeling associated 8". Retrieved 2018-10-22.
6. Zhang R, Kim AS, Fox JM, et al. (May 2018). "Mxra8 is a receptor for multiple arthritogenic alphaviruses". Nature. 557 (7706): 570–574. Bibcode:2018Natur.557..570Z. doi:10.1038/s41586-018-0121-3. PMC 5970976. PMID 29769725.

Further reading

• Yonezawa T, Ohtsuka A, Yoshitaka T, et al. (December 2003). "Limitrin, a novel immunoglobulin superfamily protein localized to glia limitans formed by astrocyte endfeet". Glia. 44 (3): 190–204. doi:10.1002/glia.10279. PMID 14603461. S2CID 42175289.
• Warnatz HJ, Schmidt D, Manke T, et al. (July 2011). "The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle". The Journal of Biological Chemistry. 286 (26): 23521–23532. doi:10.1074/jbc.M111.220178. PMC 3123115. PMID 21555518.

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