MacIsaac is a surname. Notable people with the surname include:
- Angus MacIsaac (born 1943), English educator and businessman
- Angus MacIsaac (footballer) (1900-1944) Australian rules footballer
- Ashley MacIsaac (born 1975), Canadian fiddler
- Dave MacIsaac (born 1955), Canadian musician
- Dugald MacIsaac (1901-1961), Scottish chess player
- Kevin MacIsaac [species], Canadian zoologist
- Martha MacIsaac (born 1984), Canadian actress
Surname listThis page lists people with the surname MacIsaac. If an internal link intending to refer to a specific person led you to this page, you may wish to change that link by adding the person's given name(s) to the link. Category: