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CAPG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J72, 1JHW
Identifiers
Aliases	CAPG, AFCP, HEL-S-66, MCP, capping actin protein, gelsolin like
External IDs	OMIM: 153615; MGI: 1098259; HomoloGene: 37523; GeneCards: CAPG; OMA:CAPG - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2p11.2 Start 85,394,753 bp End 85,418,432 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 C1 Start 72,521,374 bp End 72,539,966 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte skin of abdomen left lobe of thyroid gland granulocyte right lobe of thyroid gland skin of leg upper lobe of left lung right lung ectocervix gums Top expressed in granulocyte corneal stroma lip decidua ankle joint conjunctival fornix esophagus stroma of bone marrow gastrula ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-containing complex binding actin binding protein binding protein domain specific binding cadherin binding actin filament binding Cellular component cytoplasm F-actin capping protein complex melanosome centriole mitotic spindle nucleolus extracellular exosome nucleus Flemming body nucleoplasm extracellular region ruffle lamellipodium cell projection Biological process barbed-end actin filament capping extracellular matrix disassembly positive regulation of podosome assembly actin filament capping protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 822 12332 Ensembl ENSG00000042493 ENSMUSG00000056737 UniProt P40121 P24452 RefSeq (mRNA) NM_001256139 NM_001256140 NM_001747 NM_001320732 NM_001320733 NM_001320734 NM_001042534 NM_001271395 NM_001271415 NM_007599 RefSeq (protein) NP_001243068 NP_001243069 NP_001307661 NP_001307662 NP_001307663 NP_001738 n/a Location (UCSC) Chr 2: 85.39 – 85.42 Mb Chr 6: 72.52 – 72.54 Mb PubMed search
Wikidata
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Macrophage-capping protein (CAPG) also known as actin regulatory protein CAP-G is a protein that in humans is encoded by the CAPG gene.

Function

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively, spliced transcript variants have been observed, but have not been fully described.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000042493 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000056737 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dabiri GA, Young CL, Rosenbloom J, Southwick FS (Sep 1992). "Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages". J Biol Chem. 267 (23): 16545–52. doi:10.1016/S0021-9258(18)42037-6. PMID 1322908.
6. Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, Silacci P (Jul 2003). "Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress". J Biol Chem. 278 (31): 29136–44. doi:10.1074/jbc.M300598200. PMID 12754261.
7. ^ "Entrez Gene: CAPG capping protein (actin filament), gelsolin-like".
8. Ghoshdastider, U; Popp, D; Burtnick, L. D.; Robinson, R. C. (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

Further reading

• Southwick FS (1995). "Gain-of-function mutations conferring actin-severing activity to human macrophage cap G". J. Biol. Chem. 270 (1): 45–8. doi:10.1074/jbc.270.1.45. PMID 7814409.
• Mishra VS, Henske EP, Kwiatkowski DJ, Southwick FS (1995). "The human actin-regulatory protein cap G: gene structure and chromosome location". Genomics. 23 (3): 560–5. doi:10.1006/geno.1994.1543. PMID 7851883.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hirano T, Kobayashi R, Hirano M (1997). "Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein". Cell. 89 (4): 511–21. doi:10.1016/S0092-8674(00)80233-0. PMID 9160743. S2CID 15061740.
• Cabello OA, Eliseeva E, He WG, et al. (2002). "Cell cycle-dependent expression and nucleolar localization of hCAP-H". Mol. Biol. Cell. 12 (11): 3527–37. doi:10.1091/mbc.12.11.3527. PMC 60273. PMID 11694586.
• Van Impe K, De Corte V, Eichinger L, et al. (2003). "The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins". J. Biol. Chem. 278 (20): 17945–52. doi:10.1074/jbc.M209946200. PMID 12637565.
• De Corte V, Van Impe K, Bruyneel E, et al. (2005). "Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion". J. Cell Sci. 117 (Pt 22): 5283–92. doi:10.1242/jcs.01410. PMID 15454578.
• Watari A, Takaki K, Higashiyama S, et al. (2007). "Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG". Oncogene. 25 (56): 7373–80. doi:10.1038/sj.onc.1209732. PMID 16767159.
• Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.

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