Mamadou Sylla may refer to:
- Mamadou Sylla (politician) (born 1960), Guinean politician and business leader
- Mamadou Sylla (footballer, born 1975), Senegalese football defender
- Mamadou Sylla (footballer, born 1986), Senegalese football defender
- Mamadou Sylla (footballer, born 1994), Senegalese football forward
- Mamadou Sylla (footballer, born 2003), Spanish football midfielder
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