Manchester F.C. may refer to one of the following football teams:
- England
- Manchester City F.C., of the Premier League
- Manchester United F.C., of the Premier League
- Manchester Central F.C., operated from 1928 into the 1930s; now the name of an unrelated amateur club
- F.C. United of Manchester, a semi-professional team
- Other locations
- Manchester 62 F.C., in Gibraltar
- Manchester City F.C. (Sierra Leone)
- Manchester Congo Mouilla, in the Republic of the Congo
- See also
- Manchester Rugby Club, originally known as Manchester Football Club, in England
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