Manchester score is an indicator of prognosis in small cell lung cancer. It is calculated from a number of physical and biochemical markers.
A patient with small cell lung cancer scores one point for each of the following: -
- Serum lactate dehydrogenase exceeds the upper limit of the reference range.
- Serum sodium concentration less than 132 mmol/L.
- Serum alkaline phosphatase over one-and-a-half times the upper limit of the reference range.
- Serum bicarbonate less than 24.
- Karnofsky performance status less than 60.
- Extensive stage disease.
Prognosis
| Manchester score | Prognostic group | Two year survival (%) |
|---|---|---|
| 0-1 | Good | 16.2 |
| 2-3 | Medium | 2.5 |
| 4 or more | Poor | 0 |
References
- Cerny, T; Blair V; Anderson H; et al. (1987). "Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients". International Journal of Cancer. 39 (2): 146–149. doi:10.1002/ijc.2910390204. PMID 3026969. S2CID 24194711.
- Kawahara, Masaaki; Masahiro Fukuoka; Nagahiro Saijo; et al. (1996). "Prognostic factors and prognostic staging system for small cell lung cancer". Japanese Journal of Clinical Oncology. 27 (3). Oxford University Press: 158–165. doi:10.1093/jjco/27.3.158. ISSN 0368-2811. PMID 9255270.
- Maestu, I; Pastor M; Gómez-Codina J; et al. (Jun 1997). "Pretreatment prognostic factors for survival in small-cell lung cancer: a new prognostic index and validation of three known prognostic indices on 341 patients". Annals of Oncology. 8 (6): 547–553. doi:10.1023/A:1008212826956. PMID 9261523.