The Mandelin reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of ammonium metavanadate and concentrated sulfuric acid. Its primary use is for the detection of ketamine and PMA Unlike the most common reagent test chemicals, it has a deep red colour that changes to yellow if there is no alkaloid, which occurs within about 48 hours of mixing.
The United States Department of Justice method for producing the reagent is the addition of 100 mL of concentrated (95–98%) sulfuric acid to 0.5-1 g of ammonium metavanadate.
This reagent was invented by the German pharmacologist, Karl Friedrich Mandelin (1854–1906) at the University of Dorpat.
| Substance | Color |
|---|---|
| 2C-T-7 | Wine dark to Black |
| Acetaminophen | Moderate olive |
| Benzphetamine | Brilliant yellow green |
| Chlorpromazine | Dark olive |
| Cocaine | Deep orange yellow |
| Codeine | Dark olive |
| d-Amphetamine | Moderate bluish green |
| d-Methamphetamine | Dark yellowish green |
| Diacetylmorphine (Heroin) | Moderate reddish brown |
| Dimethoxymethamphetamine | Dark olive brown |
| Doxepin | Very reddish brown |
| Dristan | Greyish olive |
| Exedrine | Dark olive |
| Ketamine | Deep reddish orange |
| Mace | Moderate olive green |
| MDA | Bluish black |
| MDMA | Bluish black |
| Mescaline | Dark yellowish brown |
| Methadone | Dark greyish blue |
| Methaqualone | Very orange yellow |
| Methylphenidate | Brilliant orange yellow |
| Morphine | Dark greyish reddish brown |
| Opium | Olive black |
| Oxycodone | Dark greenish yellow |
| Procaine | Deep orange |
| Propoxyphene | Dark reddish brown |
| Psilocybin | Green |
| Paramethoxyamphetamine (PMA) | Reddish brown |
| Paramethoxymethamphetamine (PMMA) | Reddish brown |
| Salt (NaCl-HCl) | Strong orange |
See also
- Drug checking
- Dille–Koppanyi reagent
- Folin's reagent
- Froehde reagent
- Liebermann reagent
- Marquis reagent
- Mecke reagent
- Simon's reagent
- Zwikker reagent
References
- ^ "Mandelin EZ Testing Kit". EZ Test. Archived from the original on 2012-04-09. Retrieved 2012-01-27.
- "Reagent Tests UK - Mandelin reagent". Reagent Tests UK. Retrieved 3 April 2016.
- Poe, Charles F.; O'Day, David W. (2006). "A study of Mandelin's test for strychnine". Journal of the American Pharmaceutical Association. 19 (12): 1292. doi:10.1002/jps.3080191206.
- ^ "Color Test Reagents/Kits for Preliminary Identification of Drugs of Abuse" (PDF). Law Enforcement and Corrections Standards and Testing Program. July 2000. Archived (PDF) from the original on 2010-04-01. Retrieved 2011-07-24.
- "2-C-T-7 Mandelin". Reagent Base. 29 January 2015. Archived from the original on 7 March 2016. Retrieved 26 March 2015.
- ^ "Dancesafe Mandelin Reagent". Dancesafe. Retrieved 10 August 2015.
- Mahmood, Zafar Alam (2013). "Bioactive Alkaloids from Fungi: Psilocybin". Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes. Springer-Verlag. pp. 523–552. ISBN 978-3-642-22143-9.
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