Manolache may refer to several entities in Romania:
- Manolache, a village in Glina Commune, Ilfov County
- Odaia Manolache, a village in Vânători Commune, Galați County
- Valea Manolache River
- Manolache Costache Epureanu (1823-1880), politician
- Cicerone Manolache (1936-), footballer
- Ionela Târlea (1976-), formerly Ionela Târlea-Manolache, track and field athlete
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