Mary Tucker may refer to:
- Mary Evelyn Tucker, American professor
- Mary Frances Tucker (1837–1902), American poet
- Mary Logan Tucker (1858–1940), American activist
- Mary Tucker (sport shooter) (born 2001), American sports shooter
- Mary Tucker Thorp (1899–1974), American teacher, educator, and school principal
- Mary Cooper née Tucker, in the US TV series The Big Bang Theory and Young Sheldon
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