Mass destruction may refer to:
- The effect of a weapon of mass destruction that can kill a large number of humans or cause great damage
- "Mass Destruction" (song), by Faithless, 2004
- Mass Destruction (video game), 1997
- "Mass Destruction", a song from the video game Persona 3, 2006
- "Mass Destruction", the seventh episode of the animated YouTube series Murder Drones
See also
- All pages with titles beginning with Mass destruction
- All pages with titles containing Mass destruction
- Mass killing
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