Mathiassen may refer to:
- Erik Mathiassen Enge (1852–1933), Norwegian politician
- Samuel Mathiassen Føyn (1786–1854), Norwegian ship-owner and politician
- Idar Mathiassen (born 1976), Norwegian footballer
- Therkel Mathiassen (1892–1967), archaeologist, anthropologist, cartographer and ethnographer
- Gotskalk Mathiassen Seim (1818–1873), Norwegian politician
See also
- Mathiassen Mountain, on Southampton Island in the Canadian territory of Nunavut
- Mathiasen
- Mathiasin
- Mathiesen
- Mathieson
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