Mayor of Harlem is an honorific title that may refer to:
- Willie Bryant (1908–1964), emcee of the Apollo Theater
- Tommy Smalls (1926–1972), radio disc jockey in New York City
- Leslie Wyche (1944–2018), New York City community activist
- Greg Bandy (1949–), Harlem grand drummer
- Alpo Martinez (1966–), Harlem drug dealer
- Queen Mother Dr. Delois Blakely, an American nun and activist who was named Queen Mother of Harlem by Mayor Rudy Giuliani
See also
- De Mayor of Harlem, a 1985 book of poetry by American David Henderson
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