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Originally known as Maude Norton Hospital, Mercy Hospital Columbus was founded in 1917 by William Norton and cared for its first patients in the Norton Mansion. In 1952, the Norton Mansion was replaced with a modern hospital facility, which served Columbus until 1967 when a new addition was constructed. In 1999, the hospital affiliated with St. John's Regional Medical Center (Missouri) and joined Catholic Health Initiatives, changing its name to St. John's Maude Norton Hospital. In 2009, the hospital followed St. John's to the Sisters of Mercy Health System. Mercy renamed the hospital Mercy Maude Norton Hospital in 2012, and in 2014, the hospital became Mercy Hospital Columbus.