Misplaced Pages

MANF

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
(Redirected from Mesencephalic astrocyte-derived neurotrophic factor) Protein-coding gene in the species Homo sapiens

MANF
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2KVD, 2KVE, 2W51

Identifiers
AliasesMANF, ARMET, ARP, arginine-rich, mutated in early-stage tumors, arginine-rich protein, mesencephalic astrocyte-derived neurotrophic factor, mesencephalic astrocyte derived neurotrophic factor
External IDsOMIM: 601916; MGI: 1922090; HomoloGene: 4383; GeneCards: MANF; OMA:MANF - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)
Chromosome 3 (human)Genomic location for MANFGenomic location for MANF
Band3p21.2Start51,385,291 bp
End51,389,397 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • beta cell

  • body of pancreas

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • mucosa of transverse colon

  • anterior pituitary

  • left testis

  • right testis

  • pericardium
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7873

74840

Ensembl

ENSG00000145050

ENSMUSG00000032575

UniProt

P55145

Q9CXI5

RefSeq (mRNA)

NM_006010

NM_029103

RefSeq (protein)

NP_006001

n/a

Location (UCSC)Chr 3: 51.39 – 51.39 Mbn/a
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Mesencephalic astrocyte-derived neurotrophic factor (MANF), Arginine-rich, mutated in early-stage tumors (ARMET), or arginine-rich protein (ARP) is a protein that in humans is encoded by the MANF housekeeping gene.

This gene encodes a highly conserved protein whose function is known. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. With the protein size correction, this codon is now identified as the initiation codon.

MANF has cytoprotective effects in neurons and pancreatic β cells, both in vitro (cell culture) and in vivo (animal models of neurodegeneration and diabetes). Specifically, it protects dopamine neurons from endoplasmic reticulum (ER) stress-induced death. It exerts this action by binding to ERN1, the unfolded protein response (UPR) sensor in the ER, which results in the attenuation of UPR.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000145050Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Petrova P, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire AE, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW (Jun 2003). "MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons". J Mol Neurosci. 20 (2): 173–88. doi:10.1385/JMN:20:2:173. PMID 12794311. S2CID 218459504.
  5. ^ "Entrez Gene: ARMET arginine-rich, mutated in early stage tumors".
  6. Kovaleva V, Yu LY, Ivanova L, Shpironok O, Nam J, Eesmaa A, Kumpula EP, Sakson S, Toots U, Ustav M, Huiskonen JT, Voutilainen MH, Lindholm P, Karelson M, Saarma M (28 February 2023). "MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α". Cell Reports. 42 (2): 112066. doi:10.1016/j.celrep.2023.112066. PMID 36739529.

External links

Further reading


Stub icon

This article on a gene on human chromosome 3 is a stub. You can help Misplaced Pages by expanding it.

Categories: