A metallopharmaceutical is a drug that contains a metal as an active ingredient. Most commonly metallopharmaceuticals are used as anticancer or antimicrobial agents. The efficiency of metallopharmaceuticals is crucially dependent on the respective trace metal binding forms.
Examples of metallopharmaceuticals include:
- bismuth subsalicylate – a mild anti-diarrheal also used in treating peptic ulcers caused by antibiotic-resistant H. pylori
- cisplatin and carboplatin – platinum containing anticancer agents
- gold salts such as auranofin – anti-inflammatory for treatment of arthritis
- silver sulfadiazine – antibacterial
- zinc pyrithione – antibacterial and antifungal
References
- Guo J, Sadler PJ (1999). Medicinal Inorganic Chemistry. Advances in Inorganic Chemistry. Vol. 49. pp. 183–306. doi:10.1016/S0898-8838(08)60271-8. ISBN 9780120236497.
{{cite book}}:|journal=ignored (help) - Ray S, Mohan R, Singh JK, Samantaray MK, Shaikh MM, Panda D, Ghosh P (December 2007). "Anticancer and antimicrobial metallopharmaceutical agents based on palladium, gold, and silver N-heterocyclic carbene complexes". J. Am. Chem. Soc. 129 (48): 15042–53. doi:10.1021/ja075889z. PMID 17988129.
- Günther K, Weber G (1999). "Elementspeziesanalytik: Ein Überblick". Analytiker-Taschenbuch. Vol. 20. pp. 71–103. doi:10.1007/978-3-642-59914-9_3. ISBN 978-3-642-64181-7.
- Fischbach L, Evans EL (August 2007). "Meta-analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first-line therapies for Helicobacter pylori". Aliment. Pharmacol. Ther. 26 (3): 343–57. doi:10.1111/j.1365-2036.2007.03386.x. PMID 17635369. S2CID 20973127.
- Graham DY, Shiotani A (June 2008). "New concepts of resistance in the treatment of Helicobacter pylori infections". Nat. Clin. Pract. Gastroenterol. Hepatol. 5 (6): 321–31. doi:10.1038/ncpgasthep1138. PMC 2841357. PMID 18446147.
- Lokich J, Anderson N (January 1998). "Carboplatin versus cisplatin in solid tumors: an analysis of the literature". Ann. Oncol. 9 (1): 13–21. doi:10.1023/A:1008215213739. PMID 9541678.
- Go RS, Adjei AA (January 1999). "Review of the comparative pharmacology and clinical activity of cisplatin and carboplatin". J. Clin. Oncol. 17 (1): 409–22. doi:10.1200/JCO.1999.17.1.409. PMID 10458260.
- Messori L, Marcon G (2004). "Gold complexes in the treatment of rheumatoid arthritis". Met. Ions Biol. Syst. 41: 279–304. PMID 15206120.
- Gaujoux-Viala C, Smolen JS, Landewé R, Dougados M, Kvien TK, Mola EM, Scholte-Voshaar M, van Riel P, Gossec L (June 2010). "Current evidence for the management of rheumatoid arthritis with synthetic disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis". Ann. Rheum. Dis. 69 (6): 1004–9. doi:10.1136/ard.2009.127225. PMID 20447954. S2CID 30886393.
- Fuller FW (2009). "The side effects of silver sulfadiazine". J. Burn Care Res. 30 (3): 464–70. doi:10.1097/BCR.0b013e3181a28c9b. PMID 19349889. S2CID 3676574.
- Carter MJ, Tingley-Kelley K, Warriner RA (October 2010). "Silver treatments and silver-impregnated dressings for the healing of leg wounds and ulcers: a systematic review and meta-analysis". J. Am. Acad. Dermatol. 63 (4): 668–79. doi:10.1016/j.jaad.2009.09.007. PMID 20471135.
- Guthery E, Seal LA, Anderson EL (February 2005). "Zinc pyrithione in alcohol-based products for skin antisepsis: persistence of antimicrobial effects". Am J Infect Control. 33 (1): 15–22. doi:10.1016/j.ajic.2004.07.012. PMC 7119132. PMID 15685130.
Further reading
- Bonett A, Leone R, Muggia R, Howell SB, eds. (2008). Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy: Molecular Mechanisms and Clinical Applications. Humana Press. ISBN 978-1-60327-458-6.
- Clarke MJ, Sadler PJ (1999). Metallopharmaceuticals: Diagnosis and therapy. Springer. ISBN 978-3-540-65308-0.
- Clarke MJ, Sadler PJ (1999). Metallopharmaceuticals I: DNA Interactions. Springer. ISBN 978-3-540-64889-5.
- Gielen M, Tiekink ER, eds. (2005). Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine. John Wiley and Sons. ISBN 978-0-470-86403-6.
- Jones CJ, Thornback J (2007). Medicinal Applications of Coordination Chemistry. RSC Publishing. ISBN 978-0-85404-596-9.
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