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Methylecgonone reductase

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Methylecgonone reductase
Identifiers
EC no.1.1.1.334
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Methylecgonone reductase (EC 1.1.1.334, MecgoR (gene name)) is an enzyme with systematic name ecgonine methyl ester:NADP oxidoreductase. This enzyme catalyses the following chemical reaction

ecgonine methyl ester + NADP {\displaystyle \rightleftharpoons } ecgonone methyl ester + NADPH + H

The enzyme from the plant Erythroxylum coca participates in the biosynthesis of cocaine.

References

  1. Jirschitzka J, Schmidt GW, Reichelt M, Schneider B, Gershenzon J, D'Auria JC (June 2012). "Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae". Proceedings of the National Academy of Sciences of the United States of America. 109 (26): 10304–9. Bibcode:2012PNAS..10910304J. doi:10.1073/pnas.1200473109. PMC 3387132. PMID 22665766.

External links

Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
Enzymes
Activity
Regulation
Classification
Kinetics
Types
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