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Medronic acid

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(Redirected from Methylene diphosphonate) Not to be confused with mildronate or minodronate.
Medronic acid
Names
Preferred IUPAC name Methylenebis(phosphonic acid)
Other names methanediphosphonic acid; methylene diphosphonate; medronate; phosphonomethylphosphonic acid; MDP
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.016.229 Edit this at Wikidata
KEGG
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)Key: MBKDYNNUVRNNRF-UHFFFAOYSA-N
SMILES
  • O=P(O)(O)CP(=O)(O)O
Properties
Chemical formula CH6O6P2
Molar mass 176.001 g·mol
Melting point 199 to 200 °C (390 to 392 °F; 472 to 473 K)
Hazards
Lethal dose or concentration (LD, LC):
LD50 (median dose) 45-50 mg/kg (i.v., mice, rabbits)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Medronic acid (conjugate base, medronate), also known as methylene diphosphonate, is the smallest bisphosphonate. Its complex with radioactive technetium, Tc medronic acid, is used in nuclear medicine to detect bone abnormalities, including metastases.

References

  1. ^ Budavari, Susan, ed. (1996). The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (12th ed.). Merck. ISBN 0911910123.


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