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Michael Z. Lin

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Taiwanese-American biochemist and bioengineer
Michael Z. Lin
Born1973 (age 50–51)
Taipei, Taiwan
NationalityAmerican
Alma materHarvard University (BA, PhD)
University of California, Los Angeles (MD)
Known forGenetically encoded voltage indicator, optogenetics, chemogenetics
Scientific career
FieldsBiochemistry
InstitutionsStanford University
Doctoral advisorMichael E. Greenberg
Other academic advisorsRoger Y. Tsien

Michael Z. Lin (born 1973) is a Taiwanese-American biochemist and bioengineer. He is an associate professor of neurobiology and bioengineering at Stanford University. He is best known for his work on engineering optically and chemically controllable proteins.

Education and career

Lin graduated from Harvard University in 1994 with a degree in biochemical sciences summa cum laude. He subsequently trained as a PhD student studying neuronal signal transduction with Michael E. Greenberg at Harvard Medical School, graduating in 2002, and obtained a MD at UCLA in 2004. Lin then performed postdoctoral research with Chemistry Nobel Prize Laureate Roger Y. Tsien at UCSD. Since 2009, he has been a member of the faculty at the Stanford University School of Medicine.

Research

During postdoctoral training with Roger Y. Tsien, Lin developed improved red fluorescent proteins and channelrhodopsins, and pioneered the use of drug-regulated proteases for protein modification in the TimeSTAMP protein labelling method. Lin's group at Stanford University has engineered proteins with novel functions for optogenetics, chemogenetics, and synthetic biology. Notable inventions include:

  • Red fluorescent and bioluminescent proteins
  • Optically switchable proteins using an engineered green fluorescent protein
  • The ASAP genetically encoded voltage indicator family
  • Chemical control of protein expression by proteases of RNA viruses
  • Synthetic proteins that rewire cancer signals to therapeutic activation
  • SARS-CoV-2 protease inhibitors based on modifying HCV protease inhibitors

Awards and honors

See also

References

  1. "Michael Lin's Profile | Stanford Profiles". profiles.stanford.edu.
  2. "Chemistry Tree - Michael Z. Lin". academictree.org.
  3. "Michael Lin's Profile | Stanford Profiles". profiles.stanford.edu.
  4. "Chemistry Tree - Michael Z. Lin". academictree.org.
  5. Shaner, N. C.; Lin, M. Z.; McKeown, M. R.; Steinbach, P. A.; Hazelwood, K. L.; Davidson, M. W.; Tsien, R. Y. (2008). "Improving the photostability of bright monomeric orange and red fluorescent proteins". Nature Methods. 5 (6): 545–51. doi:10.1038/nmeth.1209. PMC 2853173. PMID 18454154.
  6. Lin, M. Z.; McKeown, M. R.; Ng, H. L.; Aguilera, T. A.; Shaner, N. C.; Campbell, R. E.; Adams, S. R.; Gross, L. A.; Ma, W.; Alber, T.; Tsien, R. Y. (2009). "Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals". Chemistry & Biology. 16 (11): 1169–79. doi:10.1016/j.chembiol.2009.10.009. PMC 2814181. PMID 19942140.
  7. Lin, J. Y.; Lin, M. Z.; Steinbach, P.; Tsien, R. Y. (2009). "Characterization of engineered channelrhodopsin variants with improved properties and kinetics". Biophysical Journal. 96 (5): 1803–14. Bibcode:2009BpJ....96.1803L. doi:10.1016/j.bpj.2008.11.034. PMC 2717302. PMID 19254539.
  8. Chu, J.; Oh, Y.; Sens, A.; Ataie, N.; Dana, H.; MacKlin, J. J.; Laviv, T.; Welf, E. S.; Dean, K. M.; Zhang, F.; Kim, B. B.; Tang, C. T.; Hu, M.; Baird, M. A.; Davidson, M. W.; Kay, M. A.; Fiolka, R.; Yasuda, R.; Kim, D. S.; Ng, H. L.; Lin, M. Z. (2016). "A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo". Nature Biotechnology. 34 (7): 760–7. doi:10.1038/nbt.3550. PMC 4942401. PMID 27240196.
  9. Gitig, Diana (9 November 2016). "Watching a cell cycle". Ars Technica.
  10. "Phosphorylation at the Flick of a Switch". The Scientist Magazine.
  11. Zhou, XX; Fan, LZ; Li, P; Shen, K; Lin, MZ (24 February 2017). "Optical control of cell signaling by single-chain photoswitchable kinases". Science. 355 (6327): 836–842. Bibcode:2017Sci...355..836Z. doi:10.1126/science.aah3605. PMC 5589340. PMID 28232577.
  12. Vogt, Nina (January 2020). "RAMPing up voltage indicator imaging". Nature Methods. 17 (1): 25. doi:10.1038/s41592-019-0720-4. PMID 31907465. S2CID 209897141.
  13. Villette, V; Chavarha, M; Dimov, IK; Bradley, J; Pradhan, L; Mathieu, B; Evans, SW; Chamberland, S; Shi, D; Yang, R; Kim, BB; Ayon, A; Jalil, A; St-Pierre, F; Schnitzer, MJ; Bi, G; Toth, K; Ding, J; Dieudonné, S; Lin, MZ (12 December 2019). "Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice". Cell. 179 (7): 1590–1608.e23. doi:10.1016/j.cell.2019.11.004. PMC 6941988. PMID 31835034.
  14. Chung, H. K.; Jacobs, C. L.; Huo, Y.; Yang, J.; Krumm, S. A.; Plemper, R. K.; Tsien, R. Y.; Lin, M. Z. (2015). "Tunable and reversible drug control of protein production via a self-excising degron". Nature Chemical Biology. 11 (9): 713–20. doi:10.1038/nchembio.1869. PMC 4543534. PMID 26214256.
  15. Jacobs, C. L.; Badiee, R. K.; Lin, M. Z. (2018). "StaPLs: Versatile genetically encoded modules for engineering drug-inducible proteins". Nature Methods. 15 (7): 523–526. doi:10.1038/s41592-018-0041-z. PMC 6456726. PMID 29967496.
  16. "Synthetic Protein for Targeted Cancer Therapy". BioTechniques. 14 May 2019.
  17. Chung, HK; Zou, X; Bajar, BT; Brand, VR; Huo, Y; Alcudia, JF; Ferrell JE, Jr; Lin, MZ (3 May 2019). "A compact synthetic pathway rewires cancer signaling to therapeutic effector release". Science. 364 (6439): eaat6982. doi:10.1126/science.aat6982. PMC 7053279. PMID 31048459.
  18. Westberg, Michael; Su, Yichi; Zou, Xinzhi; Ning, Lin; Hurst, Brett; Tarbet, Bart; Lin, Michael Z. (2020-09-16). "Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases". bioRxiv: 2020.09.15.275891. doi:10.1101/2020.09.15.275891. S2CID 221823586.
  19. "2011-2007 Awardees | Burroughs Wellcome Fund". www.bwfund.org.
  20. "Michael Lin". Rita Allen Foundation.
  21. "World Molecular Imaging Society Announces Early Stage Awardees for 2019". World Molecular Imaging Society. 12 September 2019.
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