Mignucci is an Italian surname. Notable people with this surname include:
- Andrés Mignucci (born 1957), Puerto Rican architect and urbanist
- Antonio Mignucci (born 1964), Puerto Rican oceanographer
- Pompeo Mignucci, (1597-1654), Italian archbishop
- Stefano Mignucci [de; it] (born 1965), Italian director
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