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Ming T. Tsuang

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American psychiatric geneticist (born 1931)
Ming T. Tsuang
莊明哲
Born (1931-11-16) November 16, 1931 (age 93)
Tainan, Taiwan
Education
Known for
Scientific career
FieldsPsychiatry
InstitutionsWashington University in St. Louis
University of California, San Diego
Harvard University

Ming Tso Tsuang (Chinese: 莊明哲; pinyin: Zhuāng Míngzhé; born November 16, 1931) is an American psychiatrist and Distinguished Professor of Psychiatry at the University of California, San Diego. He is considered a pioneering researcher in the genetic epidemiology of schizophrenia and other severe mental disorders. Tsuang has authored and co-authored more than 600 publications and serves as founding and senior editor of the American Journal of Medical Genetics Part B.

Education

Tsuang received his medical degree from National Taiwan University in 1957. He received a Ph.D. in psychiatric genetics in 1965 and a DS.c. in psychiatric genetics and epidemiology in 1981 from the University of London. Tsuang received honorary master's degrees from Brown University in 1983 and Harvard University in 1987.

Career

Tsuang holds positions at the University of California, San Diego, as a Distinguished University Professor of Psychiatry and director of the Center for Behavioral Genomics. At Harvard University, Tsuang directs the Harvard Institute of Psychiatric Epidemiology and Genetics, which he created.

Tsuang's former positions with Harvard Medical School include: Stanley Cobb Professor of Psychiatry, chairman of the Department of Psychiatry and president and superintendent of Massachusetts Mental Health Center. He was the fourth president of the International Society of Psychiatric Genetics (ISPG) and served from 2005 to 2010.

Work

Tsuang's research interests include the effects of genetic and environmental risk factors on severe mental disorders. His work focuses on preventing the onset of severe mental disorders such as schizophrenia by determining which genetic and environmental traits can lead to their onset.

After earning his doctorate degrees, Tsuang began working in 1971 at Washington University School of Medicine's Department of Psychiatry. One year later, he transitioned to the Roy J. and Lucille A. Carver College of Medicine, where he developed the Iowa 500, the first double-blind psychiatric study of families to follow up with as many index patients and their family members as possible. The preliminary results of the study suggested genetics can affect a person's liability to schizophrenia and mood disorders. The Iowa 500 and the Iowa non-500 (the study of the people excluded from the Iowa 500 sample) have informed subsequent work in psychopathology.

In 1982, Tsuang joined Alpert Medical School as a researcher and started a new stage of the Collaborative Perinatal Project (CPP). The new stage, known as the New England Family Study, assessed and followed up with a large cohort of infants whose parents had both affective and non-affective psychotic disorders. The years-long study sought the psychological effect of prenatal and early life risk conditions on the infants and found that perinatal complications do not lead to an increased risk of psychological disorder; however, infants with chronic fetal hypoxia-like symptoms did show a higher risk of cognitive impairment and psychotic disorders, including schizophrenia. The study preceded future studies of the influence perinatal complications, infections during pregnancy and family history have on predicting neuropsychiatric outcomes, physical conditions and learning disorders.

In 1985, Tsuang began working at Harvard Medical School and the Harvard School of Public Health, for which he initiated an National Institute of Mental Health (NIMH) training program in psychiatric genetics. During this time, Tsuang partnered with colleague Michael Lyons to conduct the Harvard Twin Study of Substance Abuse. The study followed 1,874 identical and 1,498 male twin pairs who served in the U.S. military between 1965 and 1975 and sought the effects of genetic, shared environmental and unique environmental factors on their illicit drug use. The study was the first to use the U.S. Department of Veterans Affairs’ Vietnam Era Twin Registry for research on illicit drug use. The results of the study suggested that genetics influence a shared vulnerability to illicit drug use and that the vulnerability varies by drug. In 2001, Tsuang and his cohort published their findings on the connection between the study's data and interviews of the participants: in participants with major depression, they found a comorbidity of illicit drug abuse and the occurrence of the drug use was higher in participants with the mood disorder than those without. This study preceded the 2012 publication of the Vietnam Era Twin Study of Aging (VESTA), which considered the behavior and genetics associated with cognitive and brain aging in randomly-selected males who participated in Tsuang's 1985 study.

Also during the 1980s, Tsuang began researching endophenotypes. His and his colleagues' research on the neuropsychological dysfunction of people with schizophrenia and their non-psychotic family members helped shift psychiatry's formerly accepted view that dysfunction was related to the disease. After multiple studies found that non-psychotic family members of people with schizophrenia showed similar mild cognitive deficits, the view that neuropsychological deficits are a central characteristic of schizophrenia became widely accepted. In 1989, Tsuang's continued his work in genetics by co-founding the NIMH Molecular Genetics Initiative and piloting the 1991 Diagnostic Interview for Genetic Studies (DIGS), which was designed to genetically assess major mood and psychotic disorders as well as their conditions. DIGS continues to serve as a benchmark assessment today.

Beginning in the 1990s, Tsuang's research on non-psychotic adults related to people with schizophrenia lead to studies focused on the psychosis prodrome to inform the early prevention and diagnosis of schizophrenia as well as interventions for the disorder. Through functional neuroimaging studies, Tsuang and his colleagues found that non-psychotic family members of people with schizophrenia showed brain activity deficits and determined that the abnormalities in the structure and function of the brain are endophenotypes for the disorder.

In 1999, in an effort to make progress toward the most effective primary prevention of schizophrenia, Tsuang and his colleagues published their discussion of schizotaxia, or liability to schizophrenia, because it is the antecedent of early symptoms of psychosis. The publication discusses the schizotaxia treatment protocol, or the evaluation of antipsychotics that may help prevent schizophrenia. The protocol, created by Tsuang, was met with controversy. However, the participants—non-psychotic family members of people with schizophrenia—volunteered for the open-label trial. In the first trial evaluation, the small sample of participants showed reduced negative symptoms and neuropsychological deficits after several weeks of risperidone use. After additional trials, the companion discussion published in 2000 was released to discuss the etiology and development of schizotaxia, review its clinical and neuropsychological aspects and conclude that it become validated as a syndrome of schizophrenia. Tsuang's cluster analysis of a larger sample of family members of people with schizophrenia proved its validity, which helped further progress toward preventing schizophrenia.

In 2003, Tsuang was appointed as University Professor at the University of California, San Diego School of Medicine and director of the university's Center of Behavioral Genomics, which he established. At this time, his research involved identifying genetic risk factors and biomarkers in order to determine the neurobiology of severe mental disorders. In 2005, Tsuang and his colleagues published a discussion of their microarray analysis of the blood cells of RNA from participants with schizophrenia, with bipolar disorder and without either disorder. The results of the study showed unique gene expression patterns for all three groups of participants as well as changes in several specific biomarker genes for schizophrenia and bipolar disorder by RT-PCR. The study is considered innovative because Tsuang created a framework for biologically diagnosing major mental illness antemortem. Tsuang's work led to further use of the biomarker strategy for research on treatment response in schizophrenia, risk state for schizophrenia in first-degree family members of people with schizophrenia and susceptibility to other disorders. In 2006, Tsuang and his colleagues published research that furthered the understanding of genetic risk factors for schizophrenia through a collaborative study of a large sample of Han Chinese families from Taiwan related to people with schizophrenia. Although the results of the exome sequencing study were similar to those of similar preceding studies, Tsuang and his colleagues were unable to definitively identify susceptibility genes for schizophrenia. However, the study did help clarify the genetic structure of schizophrenia and supported the understanding of the significance of genetic variants on risk for the disorder. Tsuang continued to pursue the identification of genetic risk factors for schizophrenia in later research.

In 2014, Tsuang and his colleagues published a discussion of the Marine Resiliency Study, which involved identifying diagnostic biomarkers that predict the appearance of post-traumatic stress disorder (PTSD) in deployed U.S. Marines. The pilot study was conducted to inform earlier diagnosis and prevention of the disorder. The investigators conducted a microarray analysis of the blood cells of RNA from U.S. Marines before and after they had returned from deployment in Iran and Afghanistan war zones. The results of the study showed the feasibility of the validation of blood-based biomarkers and helped further efforts to prevent and buffer against the effects of PTSD.

Awards

For his work as a Chair, Tsuang was awarded a Behavioral Genomics endowed chair by Harvard Medical School. In 1995, Tsuang received the ISPG Lifetime Achievement Award, which is named after him. Among other awards, he also received the 2010 Lieber Prize for Outstanding Achievement in Schizophrenia Research.

References

  1. ^ Faraone, Stephen V.; Seidman, Larry J.; Buka, Stephen; Goldstein, Jill M.; Lyons, Michael; Kremen, William S.; Glatt, Stephen J. (2013). "Festschrift Celebrating the Career of Ming T. Tsuang". American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 162 (7): 551–558. doi:10.1002/ajmg.b.32194. PMID 24132890.
  2. ^ "Editorial Board - Neuropsychiatric Genetics". Wiley Online Library. doi:10.1002/(ISSN)1552-485X. Retrieved 21 October 2018.
  3. ^ "Ming Tsuang". UCSD Profiles. Retrieved 8 July 2021.
  4. ^ "Internationally Renowned Genetic Researcher Ming Tsuang Named to Prestigious Post of "University Professor" at UCSD" (Press release). San Diego, CA: University of California, San Diego. 21 May 2003. Retrieved 13 July 2021.
  5. "Ming Tsuang". iem.ucsd.edu.
  6. "History". ISPG. 12 October 2017. Retrieved 21 October 2018.
  7. Tsuang, Ming T.; Winokur, G. (August 1975). "THE IOWA 500: Field Work in a 35-Year Follow-up of Depression, Mania, and Schizophrenia*". Canadian Psychiatric Association Journal. 20 (5): 359–365. doi:10.1177/070674377502000505. PMID 1182649. S2CID 26818505.
  8. Winokur, George (1996). The natural history of mania, depression, and schizophrenia (1st ed.). Washington, DC: American Psychiatric Press. p. 233. ISBN 9780880487269. Retrieved 8 July 2021.
  9. Strauss, John S. (1977). The Origins and Course of Psychopathology : Methods of Longitudinal Research. Boston, MA: Springer US. p. 77. ISBN 9781468423556. Retrieved 8 July 2021.
  10. Buka, Stephen L.; Seidman, Larry J.; Tsuang, Ming T.; Goldstein, Jill M. (October 2013). "The New England family study high-risk project: Neurological impairments among offspring of parents with schizophrenia and other psychoses". American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 162 (7): 653–660. doi:10.1002/ajmg.b.32181. PMID 24132897. S2CID 23754160. Retrieved 8 July 2021.
  11. Zickler, Patrick (1 November 1999). "Twin Studies Help Define the Role of Genes in Vulnerability to Drug Abuse". NIDA. Retrieved 9 July 2021.
  12. Tsuang, MT; Bar, JL; Harley, RM; Lyons, MJ (November 2001). "The Harvard Twin Study of Substance Abuse: what we have learned". Harvard Review of Psychiatry. 9 (6): 267–79. doi:10.1080/10673220127912. PMID 11600486. Retrieved 9 July 2021.
  13. Tsuang, Ming T.; Bar, Jessica L.; Harley, Rebecca M.; Lyons, Michael J. (January 2001). "The Harvard Twin Study of Substance Abuse: What We Have Learned". Harvard Review of Psychiatry. 9 (6): 267–279. doi:10.1080/10673220127912. PMID 11600486. Retrieved 9 July 2021.
  14. Kremen, William S.; Franz, Carol E.; Lyons, Michael J. (February 2013). "VETSA: The Vietnam Era Twin Study of Aging". Twin Research and Human Genetics. 16 (1): 399–402. doi:10.1017/thg.2012.86. PMC 3780387. PMID 23110957. Retrieved 14 July 2021.
  15. "Genetics and Mental Disorders: Report of the National Institute of Mental Health's Genetics Workgroup". NIMH. Retrieved 13 July 2021.
  16. Nurnberger JI, Jr; Blehar, MC; Kaufmann, CA; York-Cooler, C; Simpson, SG; Harkavy-Friedman, J; Severe, JB; Malaspina, D; Reich, T (November 1994). "Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative". Archives of General Psychiatry. 51 (11): 849–59, discussion 863-4. doi:10.1001/archpsyc.1994.03950110009002. PMID 7944874. Retrieved 13 July 2021.
  17. ^ Tsuang, M. T.; Stone, W. S.; Faraone, S. V. (September 2000). "Schizophrenia: vulnerability versus disease". Dialogues in Clinical Neuroscience. 2 (3): 257–266. doi:10.31887/DCNS.2000.2.3/mtsuang. PMC 3181615. PMID 22034456.
  18. Faraone, S. V.; Green, A. I.; Seidman, L. J.; Tsuang, M. T. (1 January 2001). ""Schizotaxia": Clinical Implications and New Directions for Research". Schizophrenia Bulletin. 27 (1): 1–18. doi:10.1093/oxfordjournals.schbul.a006849. PMID 11215539.
  19. Tsuang, M. T.; Stone, W. S.; Faraone, S. V. (December 1999). "Conceptualization of the liability for schizophrenia: clinical implications". Dialogues in Clinical Neuroscience. 1 (3): 153–164. doi:10.31887/DCNS.1999.1.3/mtsuang. PMC 3181581. PMID 22034209.
  20. Tsuang, Ming T.; Nossova, Nadine; Yager, Tom; Tsuang, Min-Min; Guo, Shi-Chin; Shyu, Kou Ge; Glatt, Stephen J.; Liew, C.C. (5 February 2005). "Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: A preliminary report". American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 133B (1): 1–5. CiteSeerX 10.1.1.1015.289. doi:10.1002/ajmg.b.30161. PMID 15645418. S2CID 23195772.
  21. Faraone, Stephen V.; Hwu, Hai-Gwo; Liu, Chih-Min; Chen, Wei J.; Tsuang, Ming-Ming; Liu, Shih-Kai; Shieh, Ming-Hsien; Hwang, Tzung-Jeng; Ou-Yang, Wen-Chen; Chen, Chun-Ying; Chen, Chwen-Cheng; Lin, Jin-Jia; Chou, Frank Huang-Chih; Chueh, Ching-Mo; Liu, Wei-Ming; Hall, Mei-Hua; Su, Jessica; Van Eerdewegh, Paul; Tsuang, Ming T. (October 2006). "Genome Scan of Han Chinese Schizophrenia Families From Taiwan: Confirmation of Linkage to 10q22.3". American Journal of Psychiatry. 163 (10): 1760–1766. doi:10.1176/appi.ajp.163.10.1760. PMID 17012687. Retrieved 14 July 2021.
  22. Tylee, Daniel S.; Chandler, Sharon D.; Nievergelt, Caroline M.; Liu, Xiaohua; Pazol, Joel; Woelk, Christopher H.; Lohr, James B.; Kremen, William S.; Baker, Dewleen G.; Glatt, Stephen J.; Tsuang, Ming T.; Marine Resiliency Study Investigators (1 January 2015). "Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: A pilot study". Psychoneuroendocrinology. 51: 472–494. doi:10.1016/j.psyneuen.2014.09.024. PMC 4199086. PMID 25311155. Retrieved 14 July 2021.
  23. "ISPG Honorific Awards". ISPG. Retrieved 21 October 2018.
  24. "Lieber Prize for Outstanding Achievement in Schizophrenia Research". Brain and Behavior Research Foundation. 2017-04-11. Retrieved 21 October 2018.

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