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Misonidazole

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Misonidazole
Names
IUPAC name (RS)-1-Methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.033.559 Edit this at Wikidata
EC Number
  • 236-931-6
KEGG
MeSH D008920
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C7H11N3O4/c1-14-5-6(11)4-9-3-2-8-7(9)10(12)13/h2-3,6,11H,4-5H2,1H3Key: OBBCSXFCDPPXOL-UHFFFAOYSA-N
  • InChI=1/C7H11N3O4/c1-14-5-6(11)4-9-3-2-8-7(9)10(12)13/h2-3,6,11H,4-5H2,1H3Key: OBBCSXFCDPPXOL-UHFFFAOYAQ
SMILES
  • COCC(CN1C=CN=C1(=O))O
Properties
Chemical formula C7H11N3O4
Molar mass 201.182 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Misonidazole is a radiosensitizer that was investigated in clinical trials. It was used in these trials for radiation therapy to cause normally resistant hypoxic tumor cells to become sensitive to the treatment.

See also

References

  1. Meißner, Rebecca; Feketeová, Linda; Illenberger, Eugen; Denifl, Stephan (2019). "Reactions in the Radiosensitizer Misonidazole Induced by Low-Energy (0–10 eV) Electrons". International Journal of Molecular Sciences. 20 (14): 3496. doi:10.3390/ijms20143496. PMC 6678818. PMID 31315268.
  2. Overgaard, Jens (2011). "Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck – A systematic review and meta-analysis". Radiotherapy and Oncology. 100 (1): 22–32. doi:10.1016/j.radonc.2011.03.004. PMID 21511351.


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