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MS 605 first appeared in maps in 2004, and has not changed significantly since. Prior to its designation in 2004, the portion of MS 605 between I-10 and US 90 was known as Mississippi Highway 975 (MS 975), with the remaining portion north of I-10 known as Mississippi Highway 981 (MS 981).
Mississippi Department of Transportation (2003). Official Highway Map of Mississippi (PDF) (Map) (2003–2004 ed.). Jackson: Mississippi Department of Transportation. Retrieved December 25, 2014.
^ Mississippi Department of Transportation (2004). Official Highway Map of Mississippi (PDF) (Map) (2004–05 ed.). Jackson: Mississippi Department of Transportation. Retrieved December 25, 2014.