Misplaced Pages

Mitochondrial 2-oxodicarboxylate carrier

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Protein-coding gene in the species Homo sapiens
SLC25A21
Identifiers
AliasesSLC25A21, ODC, ODC1, solute carrier family 25 member 21, MTDPS18
External IDsOMIM: 607571; MGI: 2445059; HomoloGene: 6988; GeneCards: SLC25A21; OMA:SLC25A21 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)
Chromosome 14 (human)Genomic location for SLC25A21Genomic location for SLC25A21
Band14q13.3Start36,677,921 bp
End37,172,606 bp
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)
Chromosome 12 (mouse)Genomic location for SLC25A21Genomic location for SLC25A21
Band12|12 C1Start56,759,419 bp
End57,244,257 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • testicle

  • stromal cell of endometrium

  • gastric mucosa

  • popliteal artery

  • tibial arteries

  • bone marrow

  • right testis

  • Achilles tendon

  • smooth muscle tissue
Top expressed in
  • proximal tubule

  • bone marrow

  • right kidney

  • hepatobiliary system

  • liver

  • human kidney

  • spermatocyte

  • lobe of liver

  • morula

  • embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

89874

217593

Ensembl

ENSG00000183032

ENSMUSG00000035472

UniProt

Q9BQT8

Q8BZ09

RefSeq (mRNA)

NM_001171170
NM_030631

NM_001167976
NM_172577

RefSeq (protein)

NP_001164641
NP_085134

NP_001161448
NP_766165

Location (UCSC)Chr 14: 36.68 – 37.17 MbChr 12: 56.76 – 57.24 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrial 2-oxodicarboxylate carrier also known as solute carrier family 25 member 21 (SLC25A21) is a protein that in humans is encoded by the SLC25A21 gene.

It is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000183032Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000035472Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21". Retrieved 2011-12-04.

Further reading

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)
By group
SLC1–10
(1):
(2):
(3):
(4):
(5):
(6):
(7):
(8):
(9):
(10):
SLC11–20
(11):
(12):
(13):
(14):
(15):
(16):
(17):
(18):
(19):
(20):
SLC21–30
(21):
(22):
(23):
(24):
(25):
(26):
(27):
(28):
(29):
(30):
SLC31–40
(31):
(32):
(33):
(34):
(35):
(36):
(37):
(38):
(39):
(40):
SLC41–48
(41):
(42):
(43):
(44):
(45):
(46):
(47):
(48):
SLCO1–4
Ion pumps
Symporter, Cotransporter
Antiporter (exchanger)
see also solute carrier disorders


Stub icon

This article on a gene on human chromosome 14 is a stub. You can help Misplaced Pages by expanding it.

Categories: