Mkhwanazi is a South African surname. Notable people with the surname include:
- Buhle Mkhwanazi (born 1990), South African footballer
- Jabulile Mkhwanazi (born 1975), South African politician
- Lindokuhle Mkhwanazi (born 1985), South African footballer
- Zibusiso Mkhwanazi (born 1983), South African businessman
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