Modrzejewski (feminine Modrzejewska) is a Polish surname. Notable people include:
- Helena Modrzejewska (1840-1909), Polish actress
- Joseph Mélèze-Modrzejewski (1930-2017), Polish-French historian
- Robert J. Modrzejewski (born 1934), American military officer
- Rudolf Modrzejewski (1861-1940), Polish-American civil engineer
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