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Molecular promiscuity

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Ability of a molecule to bind to interact with one or more other classes and subtypes of molecules

Molecular promiscuity indicates the ability of a molecule to bind to interact with one or more other classes and subtypes of molecules, in synergistic or antagonistic ways. These interactions may involve multiple paracrine, endocrine and autocrine features.

References

  1. Clark, Adrian JL; Chan, Li F (April 2017). "Promiscuity among the MRAPs". Journal of Molecular Endocrinology. 58 (3): F1–F4. doi:10.1530/JME-17-0002. PMID 28213370.
  2. Barth, Kenneth; Attardo Genco, Caroline (2016). "Microbial Degradation of Cellular Kinases Impairs Innate Immune Signaling and Paracrine TNFα Responses". Scientific Reports. 6: 34656. Bibcode:2016NatSR...634656B. doi:10.1038/srep34656. PMC 5048168. PMID 27698456.
  3. Xiaofeng, Dai; Zhifu, Mao; Songping, Xie; Hao, Zhang; Jie, Huang (January 2013). "The CXCL12/CXCR4 autocrine loop increases the metastatic potential of non-small cell lung cancer in vitro". Oncology Letters. 5 (1): 277–282. doi:10.3892/ol.2012.960. PMC 3525341. PMID 23255935.


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