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Monacolin J

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Monacolin J
Names
Preferred IUPAC name (4R,6R)-4-Hydroxy-6-{2-ethyl}oxan-2-one
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.110.662 Edit this at Wikidata
PubChem CID
UNII
CompTox Dashboard (EPA)
SMILES
  • C1C(O)2(CC3C(O)CC(=O)O3)(C)C=CC2=C1
Properties
Chemical formula C19H28O4
Molar mass 320.429 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Monacolin J is a statin made by red yeast rice. Monacolin J is a precursor to simvastatin and has potential neuroprotective activities.

It can be produced by total mycosynthesis.

References

  1. Campoy, Sonia; Sierra, Saleta; Suarez, Beatriz; Ramos, Maria C.; Velasco, Javier; Burgos, Javier S.; Adrio, Jose L. (21 July 2010). "Semisynthesis of novel monacolin J derivatives: hypocholesterolemic and neuroprotective activities". J. Antibiot. 63 (8 - August 2010): 499–505. doi:10.1038/ja.2010.76. PMID 20648024.


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