Class of enzymes
Monocyclic monoterpene ketone monooxygenase (EC 1.14.13.105 , 1-hydroxy-2-oxolimonene 1,2-monooxygenase , dihydrocarvone 1,2-monooxygenase , MMKMO ) is an enzyme with systematic name (-)-menthone,NADPH:oxygen oxidoreductase . This enzyme catalyses the following chemical reaction
(1) (-)-menthone + NADPH + H + O2
⇌
{\displaystyle \rightleftharpoons }
(4R,7S)-7-isopropyl-4-methyloxepan-2-one + NADP + H2 O
(2) dihydrocarvone + NADPH + H + O
⇌
{\displaystyle \rightleftharpoons }
4-isopropenyl-7-methyloxepan-2-one + NADP + H2 O
(3) (iso)-dihydrocarvone + NADPH + H + O2
⇌
{\displaystyle \rightleftharpoons }
6-isopropenyl-3-methyloxepan-2-one + NADP + H2 O
(4a) 1-hydroxymenth-8-en-2-one + NADPH + H + O2
⇌
{\displaystyle \rightleftharpoons }
7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + NADP + H2 O
(4b) 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one
⇌
{\displaystyle \rightleftharpoons }
3-isopropenyl-6-oxoheptanoate (spontaneous)
Monocyclic monoterpene ketone monooxygenase is a flavoprotein (FAD).
References
van der Werf MJ, Swarts HJ, de Bont JA (May 1999). "Rhodococcus erythropolis DCL14 contains a novel degradation pathway for limonene" . Applied and Environmental Microbiology . 65 (5): 2092–102. PMC 91303 . PMID 10224006 .
Van Der Werf MJ (May 2000). "Purification and characterization of a Baeyer-Villiger mono-oxygenase from Rhodococcus erythropolis DCL14 involved in three different monocyclic monoterpene degradation pathways" . The Biochemical Journal . 347 Pt 3: 693–701. doi :10.1042/0264-6021:3470693 . PMC 1221005 . PMID 10769172 .
van der Werf MJ, Boot AM (May 2000). "Metabolism of carveol and dihydrocarveol in Rhodococcus erythropolis DCL14" . Microbiology . 146 ( Pt 5): 1129–41. doi :10.1099/00221287-146-5-1129 . PMID 10832640 .
External links
Enzymes Activity
Regulation
Classification
Kinetics
Types
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