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The mouse-derived erythroleukemia cell line F4N (MEL) is an aneuploid cell line, comes from mouse inbred strain DBA/2. It was established in 1977. Eight percent of the total number of cells in culture undergo spontaneous apoptosis.
References
- Dube SK, Pragnell IB, Kluge N, Gaedicke G, Steinheider G, Ostertag W (1975). "Induction of endogenous and of spleen focus-forming viruses during dimethylsulfoxide-induced differentiation of mouse erythroleukemia cells transformed by spleen focus-forming virus". Proc Natl Acad Sci U S A. 72 (5): 1863–7. Bibcode:1975PNAS...72.1863D. doi:10.1073/pnas.72.5.1863. PMC 432647. PMID 1057176.
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