Moussaieff is a surname of Arabic origin that may refer to:
- Moussaieff Red Diamond, a 5.11-carat fancy red diamond
- Moussaieff ostracon, a pottery fragment with a forged text
People with the surname
- Dorrit Moussaieff (born 1950), First Lady of Iceland
- Jeffrey Moussaieff Masson (born 1941), American author
- Shlomo Moussaieff (businessman) (1925–2015), Israeli-born millionaire in London
- Shlomo Moussaieff (rabbi) (1852–1922), rabbi and gemstone trader from Uzbekistan, and founder of the Bukharim neighborhood of Jerusalem
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