Misplaced Pages

Multifocal micronodular pneumocyte hyperplasia

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
Micrograph showing multifocal micronodular pneumocyte hyperplasia. H&E stain.

Multifocal micronodular pneumocyte hyperplasia (MMPH) is a subtype of pneumocytic hyperplasia (hyperplasia of pneumocytes lining pulmonary alveoli).

Several synonymous terms have been done for this entity: adenomatoid proliferation of alveolar epithelium, papillary alveolar hamartoma, multifocal alveolar hyperplasia, multinodular pneumocyte hyperplasia.

These multifocal lesions are observed in tuberous sclerosis, and can be associated with lymphangioleiomyomatosis and perivascular epithelioid cell tumour (PEComa or clear cell "sugar tumor")).

It can be diagnosed through lung biopsy using thoracoscopy.

Microscopy

  • Well-demarcated, nodular lesions ranging 2–5 mm in pulmonary parenchyma.
  • Type II pneumocytes without nuclear atypia lined thickened alveolar septa and proliferated papillary structures.
  • Enlarged cuboidal cells lining mildly thickened alveolar septa.
  • Enlarged cuboidal cells have abundant, eosinophilic cytoplasm and large, round nuclei.
  • Papillary pattern with irregular margin and lymphocyte infiltration in the stroma.
  • No proliferation of immature smooth muscle cells suggestive of lymphangioleiomyomatosis.

See also

References

  1. Muir, T. E.; Leslie, K. O.; Popper, H; Kitaichi, M; Gagné, E; Emelin, J. K.; Vinters, H. V.; Colby, T. V. (1998). "Micronodular pneumocyte hyperplasia". The American Journal of Surgical Pathology. 22 (4): 465–72. doi:10.1097/00000478-199804000-00012. PMID 9537475.
  2. Ishii, M; Asano, K; Kamiishi, N; Hayashi, Y; Arai, D; Haraguchi, M; Sugiura, H; Naoki, K; Tasaka, S; Soejima, K; Sayama, K; Betsuyaku, T (2012). "Tuberous sclerosis diagnosed by incidental computed tomography findings of multifocal micronodular pneumocyte hyperplasia: A case report". Journal of Medical Case Reports. 6 (1): 352. doi:10.1186/1752-1947-6-352. PMC 3512476. PMID 23072249.
  3. Miravet Sorribes, L; Mancheño Franch, N; Batalla Bautista, L (2013). "Multifocal micronodular pneumocyte hyperplasia in a patient with tuberous sclerosis". Archivos de Bronconeumología. 49 (1): 36–7. doi:10.1016/j.arbres.2012.06.006. PMID 22884294.
  4. Shintani, Y; Ohta, M; Iwasaki, T; Ikeda, N; Tomita, E; Nagano, T; Kawahara, K (2010). "A case of micronodular pneumocyte hyperplasia diagnosed through surgical resection". Annals of Thoracic and Cardiovascular Surgery. 16 (1): 45–7. PMID 20190710.
  5. Kobashi, Y; Sugiu, T; Mouri, K; Irei, T; Nakata, M; Oka, M (2008). "Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis: Differentiation from multiple atypical adenomatous hyperplasia". Japanese Journal of Clinical Oncology. 38 (6): 451–4. doi:10.1093/jjco/hyn042. PMID 18535095.
  6. Kamiya, H; Shinoda, K; Kobayashi, N; Kudo, K; Nomura, T; Morita, T; Fujii, T (2006). "Tuberous sclerosis complex complicated by pulmonary multinodular shadows". Internal Medicine (Tokyo, Japan). 45 (5): 275–8. doi:10.2169/internalmedicine.45.1136. PMID 16595993.
  7. Kobashi, Y; Yoshida, K; Miyashita, N; Niki, Y; Matsushima, T; Irei, T (2005). "Multifocal micronodular pneumocyte hyperplasia in a man with tuberous sclerosis". Internal Medicine (Tokyo, Japan). 44 (5): 462–6. doi:10.2169/internalmedicine.44.462. PMID 15942095.
  8. Maruyama, H; Seyama, K; Sobajima, J; Kitamura, K; Sobajima, T; Fukuda, T; Hamada, K; Tsutsumi, M; Hino, O; Konishi, Y (2001). "Multifocal micronodular pneumocyte hyperplasia and lymphangioleiomyomatosis in tuberous sclerosis with a TSC2 gene". Modern Pathology. 14 (6): 609–14. doi:10.1038/modpathol.3880359. PMID 11406664.
  9. Flieder, D. B.; Travis, W. D. (1997). "Clear cell "sugar" tumor of the lung: Association with lymphangioleiomyomatosis and multifocal micronodular pneumocyte hyperplasia in a patient with tuberous sclerosis". The American Journal of Surgical Pathology. 21 (10): 1242–7. doi:10.1097/00000478-199710000-00017. PMID 9331299.
  10. Fujitaka, K; Isobe, T; Oguri, T; Yamasaki, M; Miyazaki, M; Kohno, N; Takeshima, Y; Inai, K (2002). "A case of micronodular pneumocyte hyperplasia diagnosed through lung biopsy using thoracoscopy". Respiration; International Review of Thoracic Diseases. 69 (3): 277–9. doi:10.1159/000063635. PMID 12097776. S2CID 38358651.
  11. Suzuki, K; Seyama, K; Hayashi, T; Yamashiro, Y; Shiraishi, A; Kuwatsuru, R (2013). "Reversed halo sign in tuberous sclerosis complex". Case Reports in Radiology. 2013: 1–4. doi:10.1155/2013/428501. PMC 3789275. PMID 24159404.
  12. Suzuki, K; Seyama, K; Hayashi, T; Yamashiro, Y; Shiraishi, A; Kuwatsuru, R (2013). "Reversed halo sign in tuberous sclerosis complex". Case Reports in Radiology. 2013: 1–4. doi:10.1155/2013/428501. PMC 3789275. PMID 24159404.
  13. Maruyama, H; Seyama, K; Sobajima, J; Kitamura, K; Sobajima, T; Fukuda, T; Hamada, K; Tsutsumi, M; Hino, O; Konishi, Y (2001). "Multifocal micronodular pneumocyte hyperplasia and lymphangioleiomyomatosis in tuberous sclerosis with a TSC2 gene". Modern Pathology. 14 (6): 609–14. doi:10.1038/modpathol.3880359. PMID 11406664.

External links

Category: