Mwesigwa is both a given name and a surname. Notable people with the name include:
- Mwesigwa Rukutana, Ugandan lawyer
- Andrew Mwesigwa (born 1984), Ugandan footballer
- Elizabeth Mwesigwa (born 1992), Ugandan badminton player
- Isaac Mwesigwa, Ugandan businessman
- Robert Mwesigwa, Ugandan politician
- Sheldon Mwesigwa (born 1962), Ugandan bishop
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