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N-Phenacylthiazolium bromide

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N-Phenacylthiazolium bromide
Names
Preferred IUPAC name 3-(2-Oxo-2-phenylethyl)-1,3-thiazol-3-ium bromide
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
MeSH C101705
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C11H10NOS.BrH/c13-11(8-12-6-7-14-9-12)10-4-2-1-3-5-10;/h1-7,9H,8H2;1H/q+1;/p-1Key: CEAFABGKSOIJLH-UHFFFAOYSA-M
SMILES
  • C1=CC=C(C=C1)C(=O)C2=CSC=C2.
Properties
Chemical formula C11H10BrNOS
Molar mass 284.17 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

N-Phenacylthiazolium bromide (PTB) is a cross-link breaker that in one study has been shown to prevent vascular advanced glycation end-product accumulation in diabetic rats.

References

  1. Chang, Po-Chun; Tsai, Sheng-Chueh; Chong, Li Yen; Kao, Man-Jung (July 22, 2014). "N-Phenacylthiazolium bromide inhibits the advanced glycation end product (AGE)-AGE receptor axis to modulate experimental periodontitis in rats". Journal of Periodontology. 85 (7): e268–276. doi:10.1902/jop.2014.130554. PMID 24988129.
  2. Cooper, M. E.; Thallas, V; Forbes, J; Scalbert, E; Sastra, S; Darby, I; Soulis, T (2000). "The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation". Diabetologia. 43 (5): 660–664. doi:10.1007/s001250051355. PMID 10855541.


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