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The enzyme N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase (EC 3.1.4.45) catalyzes the reaction

glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H₂O ${\displaystyle \rightleftharpoons }$ N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase. Other names in common use include α-N-acetylglucosaminyl phosphodiesterase, lysosomal α-N-acetylglucosaminidase, phosphodiester glycosidase, α-N-acetyl-D-glucosamine-1-phosphodiester, N-acetylglucosaminidase, 2-acetamido-2-deoxy-α-D-glucose 1-phosphodiester, and acetamidodeoxyglucohydrolase.

References

1. van der Drift C, van Helvoort PE, Vogels GD (1971). "S-ureidoglycolate dehydrogenase: purification and properties". Arch. Biochem. Biophys. 145 (2): 465–9. doi:10.1016/S0003-9861(71)80006-1. PMID 4399430.
2. Van der Drift L, Vogels GD, Van der Drift C (1975). "Allantoin racemase: a new enzyme from Pseudomonas species". Biochim. Biophys. Acta. 391 (1): 240–8. doi:10.1016/0005-2744(75)90170-9. PMID 237557.
3. Waheed A, Hasilik A, von Figura K (1981). "Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal α-N-acetylglucosaminyl phosphodiesterase". J. Biol. Chem. 256 (11): 5717–21. PMID 6263889.

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