N-acetylneuraminate epimerase

N-acetylneuraminate epimerase (EC 5.1.3.24, sialic acid epimerase, N-acetylneuraminate mutarotase, sialic acid mutarotase, YjhT, NanM) is an enzyme with systematic name N-acetyl-alpha-neuraminate 2-epimerase. This enzyme catalyses the following chemical reaction

N-acetyl-alpha-neuraminate

\rightleftharpoons

N-acetyl-beta-neuraminate

Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages.

References

Severi E, Müller A, Potts JR, Leech A, Williamson D, Wilson KS, Thomas GH (February 2008). "Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT". The Journal of Biological Chemistry. 283 (8): 4841–9. doi:10.1074/jbc.M707822200. PMID 18063573.

External links

N-acetylneuraminate+epimerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Isomerases: Epimerase and racemases (EC 5.1)
5.1.1: Amino acids	Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing) Serine racemase
5.1.2: Hydroxy acids	Mandelate racemase Isocitrate epimerase
5.1.3: Carbohydrates	UDP-glucose 4-epimerase N-acetylneuraminate epimerase Phosphopentose epimerase
5.1.99: Other	Methylmalonyl CoA epimerase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 5.1.3

Misplaced Pages

N-acetylneuraminate epimerase

See also

References

External links