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N-acetylphosphatidylethanolamine-hydrolysing phospholipase D (EC 3.1.4.54, NAPE-PLD, anandamide-generating phospholipase D, N-acyl phosphatidylethanolamine phospholipase D, NAPE-hydrolyzing phospholipase D) is an enzyme with systematic name N-acetylphosphatidylethanolamine phosphatidohydrolase. It catalyses the following chemical reaction

N-acylphosphatidylethanolamine + H₂O ${\displaystyle \rightleftharpoons }$ N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate

This enzyme is involved in the biosynthesis of anandamide.

See also

• Endocannabinoid System
• N-acyl phosphatidylethanolamine

References

1. Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N (February 2004). "Molecular characterization of a phospholipase D generating anandamide and its congeners". The Journal of Biological Chemistry. 279 (7): 5298–305. doi:10.1074/jbc.M306642200. PMID 14634025.
2. Wang J, Okamoto Y, Morishita J, Tsuboi K, Miyatake A, Ueda N (May 2006). "Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-β-lactamase family". The Journal of Biological Chemistry. 281 (18): 12325–35. doi:10.1074/jbc.M512359200. PMID 16527816.

• Magotti, Paola; Bauer, Inga; Igarashi, Miki; Babagoli, Masih; Marotta, Roberto; Piomelli, Daniele; Garau, Gianpiero (March 2015). "Structure of Human N-Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids". Structure. 23 (3): 598–604. doi:10.1016/j.str.2014.12.018. PMC 4351732. PMID 25684574.

External links

• N-acetylphosphatidylethanolamine-hydrolysing+phospholipase+D at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• N-acyl phosphatidylethanolamine phospholipase D (NAPEPLD ((C7orf18, FMP30, NAPE-PLD)) Human Protein Atlas

• Biology

• EC 3.1.4