Misplaced Pages

5-nitrosalicylate dioxygenase (EC 1.13.11.64, naaB (gene)) is an enzyme with systematic name 5-nitrosalicylate:oxygen 1,2-oxidoreductase (decyclizing). This enzyme catalyses the following chemical reaction

5-nitrosalicylate + O₂ ${\displaystyle \rightleftharpoons }$ 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite (overall reaction)

(1a) 5-nitrosalicylate + O₂ ${\displaystyle \rightleftharpoons }$ 4-nitro-6-oxohepta-2,4-dienedioate

(1b) 4-nitro-6-oxohepta-2,4-dienedioate ${\displaystyle \rightleftharpoons }$ 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite (spontaneous reaction)

The enzyme from soil bacterium Bradyrhizobium sp. JS329 participates in 5-nitroanthranilate degradation.

References

1. Qu Y, Spain JC (March 2010). "Biodegradation of 5-nitroanthranilic acid by Bradyrhizobium sp. strain JS329". Applied and Environmental Microbiology. 76 (5): 1417–22. doi:10.1128/AEM.02816-09. PMC 2832354. PMID 20081004.
2. Qu Y, Spain JC (June 2011). "Molecular and biochemical characterization of the 5-nitroanthranilic acid degradation pathway in Bradyrhizobium sp. strain JS329". Journal of Bacteriology. 193 (12): 3057–63. doi:10.1128/JB.01188-10. PMC 3133195. PMID 21498645.

External links

• 5-nitrosalicylate+dioxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 1.13.11