NF2, NF-2, or similar, may refer to:
Transportation
- De Havilland Venom NF.2, a British post-war night fighter aircraft
- Nickel & Foucard NF-2 Asterix, a French homebuilt aircraft
Biology
- Neurofibromatosis type II, an inherited disease
- Merlin (protein) or Neurofibromin 2, a cytoskeletal protein
- Nitrogen difluoride a chemical radical with formula •NF2
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