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NKRF
Identifiers
Aliases	NKRF, ITBA4, NRF, NFKB repressing factor
External IDs	OMIM: 300440; MGI: 1924536; HomoloGene: 84816; GeneCards: NKRF; OMA:NKRF - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq24 Start 119,588,337 bp End 119,606,443 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A3.3 Start 36,151,193 bp End 36,167,166 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in postcentral gyrus Brodmann area 23 superior frontal gyrus middle temporal gyrus gonad entorhinal cortex primary visual cortex Brodmann area 46 Pons prefrontal cortex Top expressed in pontine nuclei medial vestibular nucleus dorsal tegmental nucleus ventral tegmental area lateral hypothalamus primitive streak facial motor nucleus deep cerebellar nuclei spinal cord superior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding nucleic acid binding RNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus nucleolus nucleoplasm Biological process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55922 77286 Ensembl ENSG00000186416 ENSMUSG00000044149 UniProt O15226 Q8BY02 RefSeq (mRNA) NM_001173487 NM_001173488 NM_017544 NM_029891 RefSeq (protein) NP_060014 NP_084167 Location (UCSC) Chr X: 119.59 – 119.61 Mb Chr X: 36.15 – 36.17 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

NF-kappa-B-repressing factor is a protein that in humans is encoded by the NKRF gene.

This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes.

The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000186416 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000044149 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nourbakhsh M, Hauser H (Jan 2000). "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB". EMBO J. 18 (22): 6415–25. doi:10.1093/emboj/18.22.6415. PMC 1171704. PMID 10562553.
6. ^ "Entrez Gene: NKRF NF-kappaB repressing factor".

Further reading

• Frattini A, Faranda S, Bagnasco L, et al. (1997). "Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25". Gene. 192 (2): 291–8. doi:10.1016/S0378-1119(97)00108-X. PMID 9224902.
• Feng X, Guo Z, Nourbakhsh M, et al. (2002). "Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14212–7. Bibcode:2002PNAS...9914212F. doi:10.1073/pnas.212306199. PMC 137863. PMID 12381793.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jianfeng D, Feng J, Chaoneng J, et al. (2004). "Cloning of the correct full length cDNA of NF-kappaB-repressing factor". Mol. Cells. 16 (3): 397–401. doi:10.1016/S1016-8478(23)13818-0. PMID 14744032.
• Niedick I, Froese N, Oumard A, et al. (2005). "Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF". J. Cell Sci. 117 (Pt 16): 3447–58. doi:10.1242/jcs.01129. PMID 15226370.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dreikhausen U, Hiebenthal-Millow K, Bartels M, et al. (2005). "NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor". Mol. Cell. Biol. 25 (17): 7473–83. doi:10.1128/MCB.25.17.7473-7483.2005. PMC 1190279. PMID 16107696.
• Fukuyama R, Ng KP, Cicek M, et al. (2007). "Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells". Mol. Carcinog. 46 (5): 402–13. doi:10.1002/mc.20288. PMID 17186550. S2CID 33896417.
• Reboll MR, Oumard A, Gazdag AC, et al. (2007). "NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element". RNA. 13 (8): 1328–40. doi:10.1261/rna.545407. PMC 1924892. PMID 17592041.

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