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Iodocholesterol

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(Redirected from NP-59) Chemical compound Pharmaceutical compound

Iodocholesterol
Clinical data

Other names	Iodocholesterol; 19-Iodocholesterol; Iodocholesterol (I); 19-Iodocholest-5-en-3β-ol
ATC code	V09XA02 (WHO) (I)
Identifiers
IUPAC name (3S,8S,9S,10S,13R,14S,17R)-10-(iodomethyl)-13-methyl-17--2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopentaphenanthren-3-ol
CAS Number	37414-03-2
PubChem CID	3032874
ChemSpider	20086815
UNII	4A4E6EXB6U
CompTox Dashboard (EPA)	DTXSID80190857
ECHA InfoCard	100.048.618
Chemical and physical data
Formula	C₂₇H₄₅IO
Molar mass	512.560 g·mol
3D model (JSmol)	Interactive image
SMILES CC(C)CCC(C)3CC24C\C=C1\C(O)CC1(CI)4CC23C
InChI InChI=1S/C27H45IO/c1-18(2)6-5-7-19(3)23-10-11-24-22-9-8-20-16-21(29)12-15-27(20,17-28)25(22)13-14-26(23,24)4/h8,18-19,21-25,29H,5-7,9-17H2,1-4H3/t19-,21+,22+,23-,24+,25+,26-,27-/m1/s1 Key:FIOAEFCJGZJUPW-FTLVODPJSA-N
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Iodocholesterol, or 19-iodocholesterol, also as iodocholesterol (I) (INN) and NP-59, is a derivative of cholesterol with an iodine atom in the C19 position and a radiopharmaceutical. When the iodine atom is a radioactive isotope (iodine-125 or iodine-131), it is used as an adrenal cortex radiotracer in the diagnosis of patients suspected of having Cushing's syndrome, hyperaldosteronism, pheochromocytoma, and adrenal remnants following total adrenalectomy.

References

^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 692–. ISBN 978-1-4757-2085-3.
^ Clark OH, American Cancer Society (2003). Endocrine Tumors. PMPH-USA. pp. 124–. ISBN 978-1-55009-134-2.
Fischer M, Rosenbach EA, Glaser B, Stokar J (2023-02-24). "NP-59 Scintigraphy for Primary Aldosteronism Lateralization in a Patient With Polycystic Kidney Disease". AACE Clinical Case Reports. 9 (3): 97–98. doi:10.1016/j.aace.2023.02.006. PMC 10213608. PMID 37251975. S2CID 257212197.

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Diagnostic radiopharmaceuticals (V09)

Central nervous system

Tc (Exametazime, Pentetic acid)
I (Ioflupane (123I)
Iofetamine (123I)
Iolopride (123I)
Iomazenil)
F (Florbetapir (18F), Flutemetamol (18F))

Skeletal system

Tc (Medronic acid)

Gastrointestinal/Hepatic

Se (SeHCAT)

Respiratory system

Cardiovascular system

Inflammation/infection

Tc
In
- Capromab pendetide
- Satumomab pendetide
I (Minretumomab)
I (Iobenguane (123I))
I (Iobenguane (131I))
F
Cu
- Dotatate
Piflufolastat F-18

I
I / I (Iodocholesterol)

Radionuclides
(including tracers)

positron (PET list)

gamma ray/photon (SPECT/scintigraphy)

Cr
Co
Ga
In
I
I
I
Kr
Sm
Se
Tc
Tl
Xe

Isotopes used:

See also: Therapeutic radiopharmaceuticals (V10)

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