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NUP85
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A9Q
Identifiers
Aliases	NUP85, Nup75, FROUNT, nucleoporin 85, NPHS17
External IDs	OMIM: 170285; MGI: 3046173; HomoloGene: 11755; GeneCards: NUP85; OMA:NUP85 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.1 Start 75,205,659 bp End 75,235,758 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 E2 Start 115,455,260 bp End 115,474,811 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum right testis gonad tibial nerve left testis mucosa of transverse colon right ovary right uterine tube oocyte Top expressed in fossa condyle primitive streak zygote primary oocyte ventricular zone epiblast Paneth cell secondary oocyte Rostral migratory stream More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of nuclear pore protein binding Cellular component cytoplasm nuclear membrane membrane nuclear envelope spindle nuclear pore chromosome nuclear pore outer ring chromosome, centromeric region cytoskeleton kinetochore nucleus cytosol host cell Biological process mRNA transport protein import into nucleus viral transcription protein sumoylation positive regulation of transcription, DNA-templated chemotaxis mitotic nuclear membrane disassembly macrophage chemotaxis regulation of cellular response to heat protein transport viral process lamellipodium assembly intracellular transport of virus mRNA export from nucleus tRNA export from nucleus sister chromatid cohesion regulation of gene silencing by miRNA regulation of glycolytic process transport nephron development nucleocytoplasmic transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79902 445007 Ensembl ENSG00000125450 ENSMUSG00000020739 UniProt Q9BW27 Q8R480 RefSeq (mRNA) NM_001303276 NM_024844 NM_001330472 NM_001002929 RefSeq (protein) NP_001290205 NP_001317401 NP_079120 NP_001002929 Location (UCSC) Chr 17: 75.21 – 75.24 Mb Chr 11: 115.46 – 115.47 Mb PubMed search
Wikidata
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Nucleoporin 85 (Nup85) is a protein that in humans is encoded by the NUP85 gene.

Function

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000125450 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000020739 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Doxsey SJ, Stein P, Evans L, Calarco PD, Kirschner M (Feb 1994). "Pericentrin, a highly conserved centrosome protein involved in microtubule organization". Cell. 76 (4): 639–50. doi:10.1016/0092-8674(94)90504-5. PMID 8124707. S2CID 20503793.
6. ^ "Entrez Gene: NUP85 nucleoporin 85kDa".

Further reading

• Kapeller R, Toker A, Cantley LC, Carpenter CL (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". The Journal of Biological Chemistry. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. PMID 7592789.
• Tynan SH, Purohit A, Doxsey SJ, Vallee RB (Oct 2000). "Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin". The Journal of Biological Chemistry. 275 (42): 32763–8. doi:10.1074/jbc.M001536200. PMID 10893222.
• Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ (Sep 2002). "Proteomic analysis of the mammalian nuclear pore complex". The Journal of Cell Biology. 158 (5): 915–27. doi:10.1083/jcb.200206106. PMC 2173148. PMID 12196509.
• Mulari MT, Patrikainen L, Kaisto T, Metsikkö K, Salo JJ, Väänänen HK (May 2003). "The architecture of microtubular network and Golgi orientation in osteoclasts--major differences between avian and mammalian species". Experimental Cell Research. 285 (2): 221–35. doi:10.1016/S0014-4827(03)00033-8. PMID 12706117.
• Chang F, Re F, Sebastian S, Sazer S, Luban J (Apr 2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes". Molecular Biology of the Cell. 15 (4): 1793–801. doi:10.1091/mbc.E03-09-0691. PMC 379276. PMID 14767062.
• Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
• Terashima Y, Onai N, Murai M, Enomoto M, Poonpiriya V, Hamada T, Motomura K, Suwa M, Ezaki T, Haga T, Kanegasaki S, Matsushima K (Aug 2005). "Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis". Nature Immunology. 6 (8): 827–35. doi:10.1038/ni1222. PMID 15995708. S2CID 23496938.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Satoh M, Akatsu T, Ishkawa Y, Minami Y, Nakamura M (Mar 2007). "A novel activator of C-C chemokine, FROUNT, is expressed with C-C chemokine receptor 2 and its ligand in failing human heart". Journal of Cardiac Failure. 13 (2): 114–9. doi:10.1016/j.cardfail.2006.11.003. PMID 17395051.

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