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NUPL1

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Protein-coding gene in the species Homo sapiens
NUP58
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4JO7, 4JO9, 4JQ5, 5IJN, 5IJO

Identifiers
AliasesNUP58, PRO2463, NUPL1, NUP45, nucleoporin 58kDa, nucleoporin 58
External IDsOMIM: 607615; MGI: 1919094; HomoloGene: 40924; GeneCards: NUP58; OMA:NUP58 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)
Chromosome 13 (human)Genomic location for NUP58Genomic location for NUP58
Band13q12.13Start25,301,152 bp
End25,365,390 bp
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)
Chromosome 14 (mouse)Genomic location for NUP58Genomic location for NUP58
Band14|14 D1Start60,442,731 bp
End60,488,956 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • Achilles tendon

  • right testis

  • testicle

  • left testis

  • ganglionic eminence

  • ventricular zone

  • monocyte

  • anterior pituitary

  • cartilage tissue
Top expressed in
  • cumulus cell

  • condyle

  • primitive streak

  • hair follicle

  • conjunctival fornix

  • fossa

  • Gonadal ridge

  • ureter

  • trigeminal ganglion

  • Paneth cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9818

71844

Ensembl

ENSG00000139496

ENSMUSG00000114797

UniProt

Q9BVL2

Q8R332

RefSeq (mRNA)

NM_001008564
NM_001008565
NM_014089
NM_014778

NM_170591
NM_001362439
NM_001362440

RefSeq (protein)

NP_001008564
NP_054808

NP_733479
NP_001349368
NP_001349369

Location (UCSC)Chr 13: 25.3 – 25.37 MbChr 14: 60.44 – 60.49 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Nucleoporin p58/p45 is a protein that in humans is encoded by the NUPL1 gene.

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC).

All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000139496Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000114797Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  6. ^ "Entrez Gene: NUPL1 nucleoporin like 1".

Further reading

PDB gallery
  • 2osz: Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding 2osz: Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding


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